- Asymmetric transfer hydrogenation of α-azido acrylates
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The asymmetric transfer hydrogenation of α-azido acrylates has been explored, a range of α-hydroxy esters are produced with good enantioselectivities (80-90% ee). The reaction was conducted in the wet HCO2H/NEt3 with Ru-TsDPEN A.
- Ji, Yang,Xue, Ping,Ma, Dan-Dan,Li, Xue-Qiang,Gu, Peiming,Li, Rui
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supporting information
p. 192 - 194
(2015/02/05)
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- Organocatalytic synthesis of optically active aryllactic acid derivatives from β-ketosulfoxides
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The organocatalytic synthesis of new α-acyloxy-3-arylpropionic thioesters has been accomplished providing some enantioenriched important aryllactic acid derivatives in good yield and enantioselectivities.
- Capitta, Francesca,Melis, Nicola,Secci, Francesco,Romanazzi, Giuseppe,Frongia, Angelo
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p. 649 - 660
(2015/10/19)
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- Synthesis of unit-B of cryptophycin-24 via Sharpless asymmetric dihydroxylation
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A synthetic pathway for the synthesis of unit-B of cryptophycin-24 has been developed using Sharpless asymmetric dihydroxylation as the key step. This study shows that direct azidation of α-hydroxy acid ester using diphenylphosphoryl azide is beneficial to asymmetric synthesis of α-amino acid without the loss of chirality during the transformation.
- Borah, Arun Jyoti,Goswami, Progyashree,Barua, Nabin C.,Phukan, Prodeep
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p. 7128 - 7130
(2013/01/15)
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- An asymmetric synthesis of PPAR-γ agonist navaglitazar from (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate
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An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) γ agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and operational simplicity. Schweizerische Chemische Gesellschaft.
- Rizzo, John R.,Zhang, Tony Y.
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p. 580 - 583
(2007/10/03)
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- Unusual migrations and cyclization in the preparation of β-azido alcohols from β-hydroxy esters
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Migration of TBDMS and Boc groups from 2° alcohols to 1° alcohols during the reduction of β-hydroxy esters has been observed. Also, unusual cyclization has been noticed during tosylation of benzylic alcohol in tert-butyl ((2R)-2-hydroxy-2-phenyl ethyl)car
- Madhusudhan,Om Reddy,Ramanatham,Dubey
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p. 2719 - 2723
(2007/10/03)
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