856899-98-4

Upstream product

• 67-56-1 methanol 
• 98081-75-5 2-azido-3-(4-methoxyphenyl)acrylic acid methyl ester 
• 122517-80-0 (2S,3R)-(-)-methyl 2,3-dihydroxy-3-(p-methoxyphenyl)propionate 
• 58236-76-3 3-chloro-4-methoxy cinnamic acid 
• 832-01-9 methyl p-methoxycinnamate 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 1415012-36-0 methyl 2,3-dihydroxy3-(3-chloro-4-methoxyphenyl)propanoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 137173-40-1 (2S,3R)-methyl p-methoxycinnamate epoxide 
• 856899-97-3 2-(tert-butyl-dimethyl-silanyloxy)-3-(4-methoxy-phenyl)-propionic acid methyl ester 

Downstream Products

• 1415012-34-8 methyl 2-azido-3-(4-methoxyphenyl)propanoate 
• 94790-24-6 (2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester 
• 856900-00-0 Toluene-4-sulfonic acid (S)-1-hydroxymethyl-2-(4-methoxy-phenyl)-ethyl ester 
• 945292-58-0 (S)-2-Hydroxy-3-{4-[3-(4-phenoxy-phenoxy)-propoxy]-phenyl}-propionic acid 
• 875112-26-8 methyl (S)-2-methoxy-3-(4-methoxyphenyl)propionate 
• 23508-35-2 (S)-2-hydroxy-3-(4-hydroxy-phenyl)-propionic acid 
• 856899-99-5 (S)-3-(4-Methoxy-phenyl)-2-(toluene-4-sulfonyloxy)-propionic acid methyl ester 

Relevant academic research and scientific papers

Asymmetric transfer hydrogenation of α-azido acrylates

The asymmetric transfer hydrogenation of α-azido acrylates has been explored, a range of α-hydroxy esters are produced with good enantioselectivities (80-90% ee). The reaction was conducted in the wet HCO2H/NEt3 with Ru-TsDPEN A.

Organocatalytic synthesis of optically active aryllactic acid derivatives from β-ketosulfoxides

The organocatalytic synthesis of new α-acyloxy-3-arylpropionic thioesters has been accomplished providing some enantioenriched important aryllactic acid derivatives in good yield and enantioselectivities.

Synthesis of unit-B of cryptophycin-24 via Sharpless asymmetric dihydroxylation

A synthetic pathway for the synthesis of unit-B of cryptophycin-24 has been developed using Sharpless asymmetric dihydroxylation as the key step. This study shows that direct azidation of α-hydroxy acid ester using diphenylphosphoryl azide is beneficial to asymmetric synthesis of α-amino acid without the loss of chirality during the transformation.

An asymmetric synthesis of PPAR-γ agonist navaglitazar from (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) γ agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solvent usage, crystalline intermediates and operational simplicity. Schweizerische Chemische Gesellschaft.

Unusual migrations and cyclization in the preparation of β-azido alcohols from β-hydroxy esters

Migration of TBDMS and Boc groups from 2° alcohols to 1° alcohols during the reduction of β-hydroxy esters has been observed. Also, unusual cyclization has been noticed during tosylation of benzylic alcohol in tert-butyl ((2R)-2-hydroxy-2-phenyl ethyl)car