857640-20-1

Basic information

• Product Name: 5-CHLORO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXALDEHYDE
• Synonyms: 5-CHLORO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXALDEHYDE
• CAS NO: 857640-20-1
• Molecular Formula: C₁₁H₈ClFN₂O
• Molecular Weight: 238.65
• Mol File: 857640-20-1.mol

Chemical Properties

• Boiling Point: 369.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: -1.76±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXALDEHYDE(857640-20-1)
• EPA Substance Registry System: 5-CHLORO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXALDEHYDE(857640-20-1)

Safety Data

• Hazardous Substances Data: 857640-20-1(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 403-43-0 4-fluorobenzoyl chloride 

Relevant articles and documents

Synthesis of poly-functionalized pyrazoles under Vilsmeier-Haack reaction conditions

Synthesis of 1,3-disubstituted 5-chloro-1H-pyrazole-4-carbaldehydes was achieved by formylation of the corresponding 5-chloro-1H-pyrazoles under Vilsmeier-Haack conditions.

PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.