857729-74-9

Basic information

• Product Name: N-(piperidin-4-yl)naphthalene-1-carboxamide
• Synonyms: N-(piperidin-4-yl)naphthalene-1-carboxamide
• CAS NO: 857729-74-9
• Molecular Formula: C₁₆H₁₈N₂O
• Molecular Weight: 254.331
• Mol File: 857729-74-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(piperidin-4-yl)naphthalene-1-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(piperidin-4-yl)naphthalene-1-carboxamide(857729-74-9)
• EPA Substance Registry System: N-(piperidin-4-yl)naphthalene-1-carboxamide(857729-74-9)

Safety Data

• Hazardous Substances Data: 857729-74-9(Hazardous Substances Data)

Upstream product

• 857650-85-2 1-(1-naphthyl)-3-(1-benzylpiperidin-4-yl)urea 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 50541-93-0 4-amino-1-benzylpiperidine 

Relevant articles and documents

Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors

A series of 1- and 2-naphthamides has been prepared and tested for in vitro binding to D2L, D4.2, and 5-HT2A receptors. Different compounds display selectivity for D4.2 and 5-HT2A receptors versus Ds

Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors

In continuation of our work on N-(piperidin-4-yl)-naphthamides, the effect of substituted benzyl groups on D2L, D4.2, and 5-HT2A receptor affinity was evaluated. In the 1-naphthamide series most compounds were highly selective for D4.2 over D2L and 5-HT2A receptors. Halogen and methyl substitution in position 3 or 4 of the benzyl group increased D4.2 affinity. In the 2-naphthamide series a similar high D4.2 over D2L selectivity was retained while 5-HT2A affinity was increased. 3-Methoxy, 3-methyl, and 4-methyl substituents were favorable for D4.2 affinity while halogens reduced affinity. 2-Naphthamides with a 3-bromo- or a 3-methyl group were mixed D4.2/5-HT2A ligands similar to their unsubstituted parent compound. All compounds from both series with significant affinity for D4.2 and 5-HT2A receptors were antagonists.