- Attempted synthesis of substituted 8-oxo-4-oxa-1-azabicyclooctane through intramolecular reductive cyclisation
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Reductive intramolecular cyclisation of 2-(N-succinimido)-1-ethanol gives 8-oxo-4-oxa-1-azabicyclooctane in a good yield.On introduction of further substitution of C-1 and C-2 no cyclisation is observed.A mechanistic rational is presented.
- Mishra, Shri Krishna,Vani, T R,Rao, R Balaji
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p. 641 - 644
(2007/10/02)
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- Synthesis and hypotensive activity of some succinimide derivatives
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A series of 1--2,5-pyrrolidinedione (3) has been prepared and tested for hypotensive activity on cats and dogs.The compound 3b showed better hypotensive activity. 1--2,5-pyrrolidinediones (6) and 1--2,5-pyrrolidinediones (9) have also been synthesised and tested for their hypotensive activity.Compounds 6b, 6e, 9b and 9e showed very mild hypotensive activity.While attempting the synthesis of 12 the unexpected 11 is obtained.
- Khadilkar, B M,Bhayade, S R
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p. 338 - 342
(2007/10/02)
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