858342-22-0Relevant articles and documents
N-SULFONYLATED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXAMIDES AND METHOD OF USE
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, (2017/04/23)
The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R5, and R6 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
SUBSTITUTED PYRAZOLO[3,4-b]PYRIDIN-6-CARBOXYLIC ACIDS AND METHOD OF USE
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, (2017/05/14)
The present invention provides for compounds of formula (I) wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sj?gren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor
Mascitti, Vincent,Stevens, Benjamin D.,Choi, Chulho,McClure, Kim F.,Guimar?es, Cristiano R.W.,Farley, Kathleen A.,Munchhof, Michael J.,Robinson, Ralph P.,Futatsugi, Kentaro,Lavergne, Sophie Y.,Lefker, Bruce A.,Cornelius, Peter,Bonin, Paul D.,Kalgutkar, Amit S.,Sharma, Raman,Chen, Yue
, p. 1306 - 1309 (2011/04/16)
The design and synthesis of a GPR119 agonist bearing a 2-(2,3,6- trifluorophenyl)acetamide group is described. The design capitalized on the conformational restriction found in N-β-fluoroethylamide derivatives to help maintain good levels of potency while
Enantioselective alpha-fluorination of aldehydes using chiral organic catalysts
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Page/Page column 9; 10, (2008/06/13)
Nonmetallic, chiral organic catalysts are used to catalyze enantioselective fluorination of enolizable aldehydes. Reaction systems composed of an enolizable aldehyde, an electrophilic fluorination reagent, and a nonmetallic chiral catalyst in the form of
Enantioselective organocatalytic α-fluorination of aldehydes
Beeson, Teresa D.,MacMillan, David W. C.
, p. 8826 - 8828 (2007/10/03)
The first direct enantioselective catalytic α-fluorination of aldehydes has been accomplished. The use of enamine catalysis has provided a new organocatalytic strategy for the enantioselective fluorination of aldehydes to generate α-fluoro aldehydes, an i
