142374-19-4

Basic information

• Product Name: 4-(2-oxoethyl)piperidine-1-carboxylic acid,tert-butyl ester
• Synonyms: 1-(tert-butyloxycarbonyl)-piperidine-4-acetaldehyde;tert-Butyl 4-(formylmethyl)piperidine-1-carboxylate;tert-Butyl 4-(2-oxoethyl);n-boc-4-piperidineacetaldehyde;1-PIPERIDINE CARBOXYLIC ACID, 4-(2-OXOETHYL)-1,1-D;1-Boc-4-(2-oxo-ethyl)piperidine;tert-butyl 4-(2-oxoethyl)piperidine-1-carboxylate;tert-butyl 4-(2-oxoethyl)piperidin-1-carboxylate
• CAS NO: 142374-19-4
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.31
• Product Categories: pharmacetical
• Mol File: 142374-19-4.mol
• Article Data: 53

Chemical Properties

• Melting Point: 38-42 °C
• Boiling Point: 318.1°Cat760mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.035g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.62±0.40(Predicted)
• CAS DataBase Reference: 4-(2-oxoethyl)piperidine-1-carboxylic acid,tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-oxoethyl)piperidine-1-carboxylic acid,tert-butyl ester(142374-19-4)
• EPA Substance Registry System: 4-(2-oxoethyl)piperidine-1-carboxylic acid,tert-butyl ester(142374-19-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 142374-19-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 142374-19-4 differently. You can refer to the following data:
1. N-Boc-4-piperidineacetaldehyde is used in the preparation of benzofuran-2-carboxylic acid based Pim-1 inhibitors.
2. Reactant for synthesis of:Pim-1 inhibitorsSelective GPR119 agonists for type II diabetesReactant for: α-arylation of aldehydesEnantioselective α-benzylation of aldehydes via photoredox organocatalysisEnantioselective α?triflouromethylation of aldehydes

InChI:InChI=1/C12H21NO3/c1-12(2,3)16-11(15)13-7-4-10(5-8-13)6-9-14/h9-10H,4-8H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 60-29-7 diethyl ether 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 502609-58-7 tert-butyl 4-(2-oxoethylidene)piperidine-1-carboxylate 
• 28356-58-3 pyridine-4-acetic acid 
• 51052-78-9 4-piperidinylacetic acid 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 6622-91-9 2-(pyridine-4-yl)acetic acid hydrochloride 
• 135716-08-4 tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate 
• 622-26-4 4-(2-Hydroxyethyl)piperidine 
• 135716-09-5 tert-butyl 4-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate 
• 89151-44-0 4-(2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 206446-47-1 4-(prop-2-en-1-yl)-1-t-butoxycarbonylpiperidine 
• 146144-48-1 N-<<3(R)-(-)-<2-(piperidin-4-yl)ethyl>-2-oxopiperidin-1-yl>acetyl>-3(R)-methyl-β-alanine 
• 301221-63-6 tert-butyl 4-(1-bromo-2-oxoethyl)piperidine-1-carboxylate 
• 142355-80-4 methyl 4-piperidin-4-yl>but-2-enoate 
• 756873-25-3 tert-butyl 4-[2-hydroxy-2-(4-methoxy-2,6-dimethyl-phenyl)-ethyl]-piperidine-1-carboxylate 
• 1192064-10-0 C₂₁H₃₁NO₃ 
• 1280608-36-7 C₂₀H₂₆F₄N₂O₃ 
• 1280608-09-4 C₂₀H₂₄F₄N₂O₃ 
• 1280608-32-3 (S)-tert-butyl 4-(1-fluoro-2-hydroxyethyl)piperidine-1-carboxylate 

Relevant articles and documents

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: Modifications of the arylpropylpiperidine side chains

The 4-(3-phenylprop-1-yl)piperidine moiety of the 1,3,4-trisubstituted pyrrolidine CCR5 antagonist 1 was modified with electron deficient aromatics as well as replacement of the benzylic methylene with sulfones, gem-difluoromethylenes and alcohols in an effort to balance the antiviral potency with reasonable pharmacokinetics.

Exploiting Synergistic Catalysis for an Ambient Temperature Photocycloaddition to Pyrazoles

Sydnone-based cycloaddition reactions are a versatile platform for pyrazole synthesis, however they operate under harsh conditions (high temperature and long reaction times). Herein we report a strategy that addresses this limitation utilizing the synergistic combination of organocatalysis and visible-light photocatalysis. This new approach proceeds under ambient conditions and with excellent levels of regiocontrol. Mechanistic studies suggest that photoactivation of sydnones, rather than enamines, is key to the successful implementation of this process.

OXOPIPERAZINE DERIVATIVES

The present invention relates to novel compounds of formula (I) or formula (Ia) pharmaceutically-acceptable salts, hydrates, solvates, or stereoisomers thereof, and pharmaceutical compositions of these compounds which are useful for preventive and therapeutic use in human and veterinary medicine.