- Synthesis method of C5a receptor antagonist W-54011
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The invention discloses a synthesis method of a C5a receptor antagonist W-54011. The synthesis method comprises the following steps: performing Wittig reaction, demethylation, enol interconversion, oxidation and the like to obtain 7-methoxy-1,2,3,4-tetrah
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Paragraph 0042; 0043; 0044
(2019/04/02)
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- AMINOTRIAZOLE IMMUNOMODULATORS FOR TREATING AUTOIMMUNE DISEASES
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1-Acyl-3-(heteroaryl)-1H-1,2,4-triazol-5-amines of formula (I) are disclosed. These compounds inhibit Coagulation Factor XIIa in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.
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Paragraph 0102
(2017/08/07)
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- Asymmetric pericyclic cascade approach to spirocyclic oxindoles
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The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.
- Richmond, Edward,Duguet, Nicolas,Slawin, Alexandra M. Z.,Lebl, Tomas,Smith, Andrew D.
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supporting information; experimental part
p. 2762 - 2765
(2012/07/14)
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- Fused bicyclic carboxamide derivatives and methods of their use
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Fused bicyclic carboxamide derivatives are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed.
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Page/Page column 34
(2010/02/11)
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- NOVEL AMIDE DERIVATIVES AND MEDICINAL USE THEREOF UGS
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The present invention relates to an amide derivative of the formula (1), having a C5a receptor antagonistic action wherein each symbol is as defined in the specification. The above-mentioned amide derivative, an optically active form thereof and a pharmaceutically acceptable salt thereof are promising as an agent for the treatment or prophylaxis of diseases or syndromes caused by inflammation caused by C5a [e.g., autoimmune diseases such as rheumatism, systemic lupus erythematosus and the like, sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease, allergic diseases such as asthma and the like, atherosclerosis, cardiac infarction, brain infarction, psoriasis, Alzheimer's disease and serious organ injury (e.g., pneumonia, nephritis, hepatitis and pancreatitis and the like) due to activation of leukocytes caused by ischemia reperfusion, trauma, burn, surgical invasion and the like]. Moreover, they are useful as a therapeutic or prophylactic agent for the infectious diseases caused by bacteria and virus that invade via a C5a receptor.
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