858647-72-0Relevant articles and documents
Syntheses, characterization, and crystal structures of few dioxomolybdenum(VI) complexes incorporating tridentate hydrazones
Nandy, Madhusudan,Shit, Shyamapada,Rizzoli, Corrado,Pilet, Guillaume,Mitra, Samiran
, p. 63 - 72 (2015)
Three new cis-dioxomolybdenum(VI) complexes, [MoO2(L1)(CH3OH)] (1), [MoO2(L2)(CH3OH)] (2), and [MoO2(L3)(CH3OH)] (3) have been synthesized using three diffe
2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors
Kim, Bo-Kyoung,Ko, Hyojin,Jeon, Eun-Seok,Ju, Eun-Seon,Jeong, Lak Shin,Kim, Yong-Chul
, p. 202 - 216 (2016/05/24)
Human coxsackievirus B3 (CVB3) 3C protease plays an essential role in the viral replication of CVB3, which is a non-enveloped and positive single-stranded RNA virus belonging to Picornaviridae family, causing acute viral myocarditis mainly in children. During optimization based on SAR studies of benserazide (3), which was reported as a novel anti-CVB3 3Cpro agent from a screening of compound libraries, the 2,3,4-trihydroxybenzyl moiety of 3 was identified as a key pharmacophore for inhibitory activity against CVB3 3Cpro. Further optimization was performed by the introduction of various aryl-alkyl substituted hydrazide moieties instead of the serine moiety of 3. Among the optimized compounds, 11Q, a 4-hydroxyphenylpentanehydrazide derivative, showed the most potent inhibitory activity (IC50 Combining double low line 0.07 μM). Enzyme kinetics studies indicated that 11Q exhibited a mixed inhibitory mechanism of action. The antiviral activity against CVB3 was confirmed using the further derived analogue (14b) with more cell permeable valeryl ester group at the 2,3,4-trihydroxy moiety.
Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
Melnyk, Patricia,Leroux, Virginie,Sergheraert, Christian,Grellier, Philippe
, p. 31 - 35 (2007/10/03)
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the