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Pentaquine, also known as 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, is a chemical compound that belongs to the aminoquinoline class of drugs. It is primarily recognized for its use in medical applications, particularly in the treatment of malaria. Pentaquine possesses therapeutic potential against different forms of malaria, including those resistant to other medications. However, its usage can lead to adverse side effects and is contraindicated in certain situations, such as in individuals with G6PD deficiency due to the risk of hemolysis. It is crucial to administer pentaquine under medical supervision to ensure safe and effective treatment.

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  • 86-78-2 Structure
  • Basic information

    1. Product Name: pentaquine
    2. Synonyms: pentaquine;5-[(6-methoxyquinolin-8-yl)amino]pentyl-propan-2-yl-azanium;dihydroxy-oxido-oxo-phosphorane;N-(6-Methoxy-8-quinolinyl)-N'-(1-methylethyl)-1,5-pentanediamine;N-(6-Methoxy-8-quinolinyl)-N'-isopropyl-1,5-pentanediamine;1,5-Pentanediamine, N-(6-methoxy-8-quinolinyl)-N'-(1-methylethyl)-;5428-64-8 (Phosphate[1:1]);Ccris 6978
    3. CAS NO:86-78-2
    4. Molecular Formula: C18H27N3O
    5. Molecular Weight: 301.43
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 86-78-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 442.55°C (rough estimate)
    3. Flash Point: 239.7°C
    4. Appearance: /
    5. Density: 1.0656 (rough estimate)
    6. Vapor Pressure: 4.17E-09mmHg at 25°C
    7. Refractive Index: 1.5785 (estimate)
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: pentaquine(CAS DataBase Reference)
    11. NIST Chemistry Reference: pentaquine(86-78-2)
    12. EPA Substance Registry System: pentaquine(86-78-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. RIDADR: 1544
    5. WGK Germany:
    6. RTECS:
    7. HazardClass: 6.1(b)
    8. PackingGroup: III
    9. Hazardous Substances Data: 86-78-2(Hazardous Substances Data)

86-78-2 Usage

Uses

Used in Medical Applications:
Pentaquine is used as an antimalarial drug for the treatment of malaria. It is effective against various forms of the disease, including those resistant to other medications.
Used in Malaria Treatment:
Pentaquine is used as a therapeutic agent for combating malaria, particularly in cases where other treatments have been ineffective. It is closely related to other malaria medications like primaquine and tafenoquine, which also belong to the aminoquinoline class of drugs.
Used in Drug Administration:
Pentaquine is used as a medication under medical supervision to ensure safe and effective treatment. Due to its potential side effects and contraindications, such as the risk of hemolysis in individuals with G6PD deficiency, it is crucial to administer pentaquine with caution and monitor patients closely during treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 86-78-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 6 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 86-78:
(4*8)+(3*6)+(2*7)+(1*8)=72
72 % 10 = 2
So 86-78-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H27N3O/c1-14(2)19-9-5-4-6-10-20-17-13-16(22-3)12-15-8-7-11-21-18(15)17/h7-8,11-14,19-20H,4-6,9-10H2,1-3H3

86-78-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(6-methoxyquinolin-8-yl)-N'-propan-2-ylpentane-1,5-diamine

1.2 Other means of identification

Product number -
Other names Pentachina

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86-78-2 SDS

86-78-2Relevant articles and documents

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling

Ganesh, Thota,Min, Jaeki,Thepchatri, Pahk,Du, Yuhong,Li, Lian,Lewis, Iestyn,Wilson, Larry,Fu, Haian,Chiosis, Gabriela,Dingledine, Raymond,Liotta, Dennis,Snyder, James P.,Sun, Aiming

, p. 6903 - 6910 (2008/12/22)

The molecular chaperone Hsp90 plays important roles in maintaining malignant phenotypes. Recent studies suggest that Hsp90 exerts high-affinity interactions with multiple oncoproteins, which are essential for the growth of tumor cells. As a result, research has focused on finding Hsp90 probes as potential and selective anticancer agents. In a high-throughput screening exercise, we identified quinoline 7 as a moderate inhibitor of Hsp90. Further hit identification, SAR studies, and biological investigation revealed several synthetic analogs in this series with micromolar activities in both fluorescent polarization (FP) assay and a cell-based Western blot (WB) assay. These compounds represent a new class of Hsp90 inhibitors with simple chemical structures.

8-Aminoquinolines as anticoccidials - Part III

Armer, Richard E.,Barlow, Jacqueline S.,Chopra, Narinder,Dutton, Christopher J.,Greenway, David H.J.,Greenwood, Sean D.W.,Lad, Nita,Shaw, Jonothan,Thompson, Adrian P.,Thong, Kam-Wah,Tommasini, Ivan

, p. 2425 - 2430 (2007/10/03)

Analogues of the antimalarial pentaquine, 1, in which the nature of the side-chain on the 8-amino position was varied, were prepared and evaluated for anticoccidial activity both in vitro and in vivo. Specifically, both the inter-nitrogen distance and the nature of the terminal amino group were investigated. Novel analogues of equal or improved efficacy in vitro and in vivo to pentaquine were discovered.

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