860205-92-1

Basic information

• Product Name: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid
• Synonyms: 3-Quinolinecarboxylicacid,7-bromo-4-hydroxy-(5CI);7-bromo-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;7-Bromo-4-hydroxy-3-quinolinecarboxylic acid;4-Hydroxy-7-broMoquinoline-3-caroboxylic acid;7-bromo-4-oxo-1H-quinoline-3-carboxylic acid
• CAS NO: 860205-92-1
• Molecular Formula: C10H6BrNO3
• Molecular Weight: 268.06
• EINECS: -0
• Product Categories: QUINOLINE
• Mol File: 860205-92-1.mol

Chemical Properties

• Boiling Point: 408.023 °C at 760 mmHg
• Flash Point: 200.565 °C
• Appearance: /
• Density: 1.862
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.65±0.30(Predicted)
• CAS DataBase Reference: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(860205-92-1)
• EPA Substance Registry System: 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid(860205-92-1)

Safety Data

• Hazardous Substances Data: 860205-92-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
7-Bromo-4-hydroxy-3-quinolinecarboxylic acid is used as a chemical intermediate for the synthesis of new drug candidates due to its structural features and potential biological activities. Its presence of a bromine atom and hydroxyl group may contribute to the development of compounds with antibacterial, antiviral, or anticancer properties.
Used in Antibacterial Applications:
In the field of antibacterial research, 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid is used as a potential active ingredient for the development of new antibiotics, leveraging its structural properties to target and inhibit bacterial growth.
Used in Antiviral Applications:
7-Bromo-4-hydroxy-3-quinolinecarboxylic acid is utilized as a component in antiviral drug research, where its unique structure may help in the design of compounds capable of inhibiting viral replication and reducing viral load.
Used in Anticancer Applications:
In oncology, 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid is employed as a precursor in the synthesis of anticancer agents, potentially leading to the discovery of new chemotherapeutic drugs that can target cancer cells effectively.
Further research and testing are essential to fully explore the potential uses and effects of 7-Bromo-4-hydroxy-3-quinolinecarboxylic acid, ensuring its safe and effective application in various industries.

Upstream product

• 208580-23-8 ethyl 7-bromo-4-hydroxyquinoline-3-carboxylate 
• 351893-47-5 ethyl α-carbethoxy-β-m-bromoanilinoacrylate 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 82121-06-0 4-hydroxy-7-bromoquinoline 
• 1445786-54-8 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclopentyloxy)benzoic acid 
• 1445788-84-0 methyl 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-(cyclohexyloxy)benzoate 
• 1445786-50-4 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-(cyclohexyloxy)benzoic acid 
• 1445786-48-0 sec-butyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate 
• 1445788-80-6 3-({3-carbamoyl-7-[2,4-bis(methyloxy)-5-pyrimidinyl]-4-quinolinyl}amino)-5-hydroxybenzoic acid 
• 1445786-46-8 cyclopentyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate 
• 1445786-44-6 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoic acid 
• 1445786-42-4 methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-isopropoxybenzoate 
• 1445786-38-8 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-((cyclohexylmethyl)amino)benzoic acid 
• 1445788-58-8 4-((3-carbamoyl-5-(4-fluorophenoxy)phenyl)amino)-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide 
• 1445788-56-6 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-(dimethylcarbamoyl)-5-sulfamoylphenyl)amino)quinolin-3-carboxamide 
• 1445788-54-4 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-methoxy-5-sulfamoylphenyl)amino)quinolin-3-carboxamide 
• 1445788-52-2 7-(2,4-dimethoxypyrimidin-5-yl)-4-((3-(pyrrolidine-1-carbonyl)-5-sulfamoylphenyl)amino)quinolin-3-carboxamide 

Relevant articles and documents

Structure-activity relationships for antiplasmodial activity among 7- substituted 4-aminoquinolines

Aminoquinolines (AQs) with diaminoalkane side chains (-HNRNEt2) shorter or longer than the isopentyl side chain [-HNCHMe(CH2)3NEt2] of chloroquine are active against both chloroquine-susceptible and -resistant Plasmodium falciparum. (De, D.; et al. Am. J. Trop. Med. Hyg. 1996, 55, 579-583). In the studies reported here, we examined structure-activity relationships (SARs) among AQs with different N,N-diethyldiaminoalkane side chains and different substituents at the 7-position occupied by Cl in chloroquine. 7-Iodo- and 7- bromo-AQs with diaminoalkane side chains [-HN(CH2)2NEt2, -HN(CH2)3NEt2, or -HNCHMeCH2NEt2] were as active as the corresponding 7-chloro-AQs against both chloroquine-susceptible and -resistant P. falciparum (IC50s of 3-12 nM). In contrast, with one exception, 7-fluoro-AQs and 7-trifluoromethyl-AQs were less active against chloroquine-susceptible P. falciparum (IC50s of 15-50 nM) and substantially less active against chloroquine-resistant P. falciparum (IC50s of 18-500 nM). Furthermore, most 7-OMe-AQs were inactive against both chloroquine-susceptible (IC50s of 17-150 nM) and -resistant P. falciparum (IC50s of 90-3000 nM).