Carboxy Group as a Remote and Selective Chelating Group for C?H Activation of Arenes
The first example of carboxy group assisted, remote-selective C(sp2)?H activation with a PdII catalyst has been developed and proceeds through a possible κ2 coordination of the carboxy group, thus suppressing the ortho-C?H activation through κ1 coordination. Besides meta-C?H olefination, direct meta-arylation of hydrocinnamic acid derivatives with low-cost aryl iodides has been achieved for the first time. These findings may motivate the exploration of novel reactivities of the carboxy assisted C?H activation reactions with intriguing selectivities.
Li, Shangda,Wang, Hang,Weng, Yunxiang,Li, Gang
supporting information
p. 18502 - 18507
(2019/11/14)
The Chemistry of 2H-1,3-Benzoxazine-2,4-(1H)dione (Isatoic Anhydride). 8. A One Step Synthesis of the Quinindoline Ring System and Related Compounds
The reaction between N-substituted isatoic anhydrides and the carbanion generated from 3-methylthiooxindole to produce the quinindoline ring skeleton is discussed.Analogous reactions of azaisatoic anhydride 6 and tricyclic anhydride 8 produces the 4-aza analog 7 and pentacycle 9.Some spectral data is also described.
Coppola, Gary M.
p. 1785 - 1787
(2007/10/02)
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