- Near-infrared absorbing merocyanine dyes for bulk heterojunction solar cells
-
A series of near-infrared absorbing merocyanine dyes bearing the strong electron-accepting 2-oxo-5-dicyanomethylene-pyrrolidine unit was synthesized and applied in combination with PC61BM and PC71BM in solution-processed photoactive
- Buerckstuemmer, Hannah,Kronenberg, Nils M.,Meerholz, Klaus,Wuerthner, Frank
-
supporting information; experimental part
p. 3666 - 3669
(2010/11/04)
-
- Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors
-
C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.
- Zhao, Hongyu,Serby, Michael D.,Xin, Zhili,Szczepankiewicz, Bruce G.,Liu, Mei,Kosogof, Christi,Liu, Bo,Nelson, Lissa T. J.,Johnson, Eric F.,Wang, Sanyi,Pederson, Terry,Gum, Rebecca J.,Clampit, Jill E.,Haasch, Deanna L.,Abad-Zapatero, Cele,Fry, Elizabeth H.,Rondinone, Cristina,Trevillyan, James M.,Sham, Hing L.,Liu, Gang
-
p. 4455 - 4458
(2007/10/03)
-
- Inhibitors of c-Jun N-terminal kinases
-
The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.
- -
-
Page/Page column 35; 67
(2008/06/13)
-
- Syntheses with Nitriles, LXXIV. - 3-Amino-4,4-dicyano-3-butenoate, a Synthetically Useful Dimer from Malononitrile and Cyanoacetate
-
An improved synthesis of 3-amino-4,4-dicyano-3-butenoate (4) (a codimer from cyanoacetate and malononitrile) is described.The 13C NMR data and pKa value of 4 are compared with those of the isomeric codimer 3 and the dimers 1 and 2.Reaction of 4 with acids or bases leads to the 2(1H)-pyridones 8 and 9, respectively.Conversions of 4 with aldehydes, ketones, and nitroso compounds give the products 11,14, and 15 as well as the benzopyran derivatives 12 and the 2-oxochinoline derivative 13 when using 2-hydroxy- and 2-aminobenzaldehydes. 4 reacts with formamidine to yield the dihydropyrimidine derivative 17 and with sulfur to give the 3,5-diamino-4-cyano-2-thiophenecarboxylates (18).
- Mittelbach, Martin,Junek, Hans
-
p. 533 - 544
(2007/10/02)
-
- Self-condensation of Ethyl 3-Amino-3-ethoxypropenoate and related Reactions
-
The acid-catalyzed self-condensation of the title compound 1a - the major component of the equilibrium 1a1b - yields via elimination of ethanol a mixture of pyridine, pyrimidine, and s-triazine derivatives (Scheme 1, Table1).In order to elucidate the course of this reaction, the ester 1 has been treated with CH-acids 12a, b to give 13a, b.Condensation of 1 with the ketene O,N-acetal 14 under self-condensation conditions mainly yields the substituted 4(1H)-pyridinone 8b.
- Ivanov, Ivo C.,Sulay, Piroschka B.,Dantchev, Damian K.
-
p. 753 - 760
(2007/10/02)
-