86165-77-7

Upstream product

• 109-77-3 malononitrile 
• 39632-87-6 ethyl 3-amino-3-ethoxypropenoate 
• 34570-16-6 ethyl malonic monoimidate hydrochloride 
• 34570-16-6 ethyl β-amino-β-ethoxyacrylate hydrochloride 

Downstream Products

• 102266-74-0 3-Amino-4,4-dicyan-2-<4-(methylamino)phenylimino>-3-butensaeure-ethylester 
• 102266-59-1 4-Amino-2-ethoxy-1,6-dihydro-6-oxo-3-pyridincarbonitril 
• 111680-57-0 3-Amino-4,4-dicyano-2-(p-tolyl-hydrazono)-but-3-enoic acid ethyl ester 
• 109613-74-3 4-Amino-5-cyan-1,6-dihydro-6-imino-1-(2,4-dichlorphenyl)-3-pyridazin-carbonsaeure-ethylester 
• 102266-65-9 3-Amino-4,4-dicyan-1-(3,4,5-trimethoxyphenyl)-1,3-butadien-2-carbonsaeure-ethylester 
• 109613-75-4 4-Amino-5-cyan-1,6-dihydro-6-imino-1-(3-chlorphenyl)-3-pyridazin-carbonsaeure-ethylester 
• 109613-72-1 4-Amino-5-cyan-1,6-dihydro-6-imino-1-(2,4-dimethylphenyl)-3-pyridazin-carbonsaeure-ethylester 
• 109613-77-6 4-Amino-5-cyan-1,6-dihydro-6-imino-1-(3,5-bistrifluormethylphenyl)-3-pyridazin-carbonsaeure-ethylester 
• 109613-76-5 4-Amino-5-cyan-1,6-dihydro-6-imino-1-(4-bromphenyl)-3-pyridazin-carbonsaeure-ethylester 
• 102266-76-2 3-Amino-4,4-dicyan-2-<4-(diethylamino)phenylimino>-3-butensaeure-ethylester 
• 1272323-13-3 5-phenylpyrido[2,3-b]-1,5-benzodiazepine 
• 102266-59-1 4-amino-2-ethoxy-6-hydroxynicotinonitrile 
• 150799-66-9 C₁₃H₁₁N₅O₂ 
• 128756-06-9 1,2,4-Triamino-6-oxo-5-p-tolylazo-1,6-dihydro-pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Near-infrared absorbing merocyanine dyes for bulk heterojunction solar cells

A series of near-infrared absorbing merocyanine dyes bearing the strong electron-accepting 2-oxo-5-dicyanomethylene-pyrrolidine unit was synthesized and applied in combination with PC61BM and PC71BM in solution-processed photoactive

Inhibitors of c-Jun N-terminal kinases

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors

C-Jun NH2 terminal kinases (JNKs) are important cell signaling enzymes. JNK1 plays a central role in linking obesity and insulin resistance. JNK2 and JNK3 may be involved in inflammatory and neurological disorders, respectively. Small-molecule JNK inhibitors could be valuable tools to study the therapeutic benefits of inhibiting these enzymes and as leads for potential drugs targeting JNKs. In this report, we disclose a series of potent and highly selective JNK inhibitors with good pharmacokinetic profiles.

Syntheses with Nitriles, LXXIV. - 3-Amino-4,4-dicyano-3-butenoate, a Synthetically Useful Dimer from Malononitrile and Cyanoacetate

An improved synthesis of 3-amino-4,4-dicyano-3-butenoate (4) (a codimer from cyanoacetate and malononitrile) is described.The 13C NMR data and pKa value of 4 are compared with those of the isomeric codimer 3 and the dimers 1 and 2.Reaction of 4 with acids or bases leads to the 2(1H)-pyridones 8 and 9, respectively.Conversions of 4 with aldehydes, ketones, and nitroso compounds give the products 11,14, and 15 as well as the benzopyran derivatives 12 and the 2-oxochinoline derivative 13 when using 2-hydroxy- and 2-aminobenzaldehydes. 4 reacts with formamidine to yield the dihydropyrimidine derivative 17 and with sulfur to give the 3,5-diamino-4-cyano-2-thiophenecarboxylates (18).

Self-condensation of Ethyl 3-Amino-3-ethoxypropenoate and related Reactions

The acid-catalyzed self-condensation of the title compound 1a - the major component of the equilibrium 1a1b - yields via elimination of ethanol a mixture of pyridine, pyrimidine, and s-triazine derivatives (Scheme 1, Table1).In order to elucidate the course of this reaction, the ester 1 has been treated with CH-acids 12a, b to give 13a, b.Condensation of 1 with the ketene O,N-acetal 14 under self-condensation conditions mainly yields the substituted 4(1H)-pyridinone 8b.