862135-60-2

Basic information

• Product Name: 5-broMo-2,3-dihydro-1H-inden-2-yl acetate
• Synonyms: 5-broMo-2,3-dihydro-1H-inden-2-yl acetate;5-Bromo-2,3-dihydro-1H-inden-2-ol 2-acetate;5-Bromo-2,3-dihydro-1H-inden-2-ol acetate;Acetic acid 5-broMo-indan-2-yl ester
• CAS NO: 862135-60-2
• Molecular Formula: C₁₁H₁₁BrO₂
• Molecular Weight: 255.10784
• Mol File: 862135-60-2.mol

Chemical Properties

• Melting Point: 75-77℃
• Appearance: /
• Density: 1.50
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-broMo-2,3-dihydro-1H-inden-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-2,3-dihydro-1H-inden-2-yl acetate(862135-60-2)
• EPA Substance Registry System: 5-broMo-2,3-dihydro-1H-inden-2-yl acetate(862135-60-2)

Safety Data

• Hazardous Substances Data: 862135-60-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2,3-dihydro-1h-inden-2-yl acetate is used as a key intermediate in the synthesis of various pharmaceuticals for its unique structural features and reactivity. Its presence in the molecular structure can contribute to the development of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
As a reagent in organic synthesis, 5-Bromo-2,3-dihydro-1h-inden-2-yl acetate is utilized for its ability to participate in a variety of chemical reactions, facilitating the creation of complex organic compounds for research and industrial applications.
Used in Bioactive Compound Research:
5-Bromo-2,3-dihydro-1h-inden-2-yl acetate is used as a subject of study in bioactive compound research to explore its potential properties that may contribute to the development of new chemical entities with medicinal or biological significance.
Used in Chemical Process Development:
In the field of chemical process development, 5-Bromo-2,3-dihydro-1h-inden-2-yl acetate is employed to enhance or create new processes that leverage its unique chemical characteristics, potentially leading to more efficient or effective methods in chemical production.
Used in Industrial Applications:
5-Bromo-2,3-dihydro-1h-inden-2-yl acetate may also find use in various industrial applications beyond pharmaceuticals and organic synthesis, taking advantage of its chemical properties for specific technical needs or improvements in existing processes.

Upstream product

• 4254-29-9 indan-2-ol 
• 4254-31-3 2-acetoxyindane 

Downstream Products

• 174349-93-0 5-bromo-1H-inden-2(3H)-one 
• 942317-96-6 (E)-3-(2-acetoxyindan-5-yl)-2-tert-butoxycarbonylaminoacrylic acid benzyl ester 
• 73536-88-6 5-bromo-2-aminoindane 
• 862135-61-3 5-bromo-2,3-dihydro-1H-inden-2-ol 

Relevant articles and documents

ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L1, M and R11 are as defined herein. The compounds of Formula (I) are selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

Daucus carota and baker's yeast mediated bio-reduction of prochiral ketones

Stereoselective reduction of prochiral ketones to the corresponding alcohols using biocatalysts has attracted much attention, from the viewpoint of green chemistry. Asymmetric reduction of indanone, tetralone and hydroxyl trimonoterpene ketones to the corresponding enantiomerically pure (S)-alcohols, using Daucus carota plant homogenate and fermented baker's yeast cells, is described. The present study illustrates the broad substrate selectivity of the dehydrogenase enzymes present in the D. carota in the synthesis of a wide range of chiral secondary alcohols of biological importance.

Concise syntheses of 2-aminoindans via indan-2-ol

2-Amino-5,6-dimethoxyindan hydrochloride was synthesized in seven steps and with an overall yield of 48%. Indan-2-ol was converted to 5,6-dibromo-indan-2- ol in three steps by acetylation, electrophilic bromination and deacetylation. Dimethoxylation of 5,6-dibromoindan-2-ol with NaOCH3 in the presence of CuI gave 5,6-dimethoxy-indan-2-ol, which was converted to 2-amino-5,6-dimethoxyindan hydrochloride by azidation, followed by Pd-C catalyzed hydrogenation. Similarly, 2-amino-5-bromoindan was synthesized in five steps and with an overall yield of 50%. Indan-2-ol was converted to 2-aminoindan by azidation followed by Pd-C catalyzed hydrogenation. The reaction of 2-aminoindan with 2.5 equiv Br2 afforded 2-amino-5,6- dibromoindan.