73536-88-6

Basic information

• Product Name: 5-BROMO-INDAN-2-YLAMINE
• Synonyms: 5-BROMOINDAN-2-AMINE;5-BROMO-INDAN-2-YLAMINE;5-Bromo-2-indanamine HCl;5-BroMo-2,3-dihydro-1H-inden-2-aMine;5-Bromo-2-indanamine hydrochloride;5-bromo-2-aminoindane
• CAS NO: 73536-88-6
• Molecular Formula: C₉H₁₀BrN
• Molecular Weight: 212.09
• Mol File: 73536-88-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-BROMO-INDAN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-INDAN-2-YLAMINE(73536-88-6)
• EPA Substance Registry System: 5-BROMO-INDAN-2-YLAMINE(73536-88-6)

Safety Data

• Hazardous Substances Data: 73536-88-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron, 61, p. 6801, 2005 DOI: 10.1016/j.tet.2005.04.069

Upstream product

• 2338-18-3 2-aminoindane hydrochloride 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 
• 321352-52-7 5-bromo-2-aminoindane hydrobromide 
• 862135-61-3 5-bromo-2,3-dihydro-1H-inden-2-ol 
• 4254-31-3 2-acetoxyindane 
• 4254-29-9 indan-2-ol 
• 862135-55-5 5,6-dibromoindan-2-ol acetate 
• 862135-56-6 5,6-dibromoindan-2-ol 
• 862135-60-2 5-bromoindan-2-ol acetate 
• 862135-63-5 2-azido-5,6-dibromoindan 
• 862135-62-4 2-azido-5-bromoindan 

Downstream Products

• 322692-47-7 1,1-dimethylethyl (5-bromo-2,3-dihydro-1H-inden-2-yl)carbamate 
• 370861-57-7 (S)-5-bromo-2-aminoindan (1R)-(-)-10-camphorsulfonate salt 
• 321352-54-9 (R)-5-bromo-2-aminoindan (1S)-(+)-10-camphorsulfonate salt 
• 944707-45-3 C₁₅H₁₄BrNO₂S 

Relevant articles and documents

Substituted ring compound and its method and use thereof

The invention provides a substituted cyclic compound as well as a use method and application thereof. The compound is a compound as shown in a formula (I) or stereoisomers, stereomers, tautomers, nitric oxides, solvates, metabolites and pharmaceutically acceptable salts or prodrugs of the compound as shown in the formula (I). The invention further provides a medicament composition containing the compound. The compound and the medicament composition are capable of regulating the activity of protein kinase in a biological sample body and are used for protecting, treating or relieving proliferative diseases of patients. The formula (I) is as shown in the specification.

SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE

Compounds of formula (I) and pharmaceutically acceptable salts thereof, which are modulators of secreted frizzled related protein- 1, are disclosed. The compounds, and compositions containing the compounds, can be used to treat various diseases and disord

Concise syntheses of 2-aminoindans via indan-2-ol

2-Amino-5,6-dimethoxyindan hydrochloride was synthesized in seven steps and with an overall yield of 48%. Indan-2-ol was converted to 5,6-dibromo-indan-2- ol in three steps by acetylation, electrophilic bromination and deacetylation. Dimethoxylation of 5,6-dibromoindan-2-ol with NaOCH3 in the presence of CuI gave 5,6-dimethoxy-indan-2-ol, which was converted to 2-amino-5,6-dimethoxyindan hydrochloride by azidation, followed by Pd-C catalyzed hydrogenation. Similarly, 2-amino-5-bromoindan was synthesized in five steps and with an overall yield of 50%. Indan-2-ol was converted to 2-aminoindan by azidation followed by Pd-C catalyzed hydrogenation. The reaction of 2-aminoindan with 2.5 equiv Br2 afforded 2-amino-5,6- dibromoindan.