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CAS

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862505-00-8

LY2228820 is a potent and selective inhibitor of p38α and p38β, two closely related isoforms of the p38 mitogen-activated protein kinase (MAPK) family. It is a small molecule compound that has been extensively tested for its therapeutic potential in various inflammatory conditions, making it a promising candidate for further clinical development.

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  • 7-(2-tert-Butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine

    Cas No: 862505-00-8

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  • 862505-00-8 Structure

  • Basic information

    1. Product Name: LY2228820
    2. Synonyms: 5-[2-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine;Ralimetinib dimesylate;7-(2-tert-Butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-am;7-(2-tert-Butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine
    3. CAS NO:862505-00-8
    4. Molecular Formula: C24H29FN6
    5. Molecular Weight: 420.5256632
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 862505-00-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.23
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: LY2228820(CAS DataBase Reference)
    10. NIST Chemistry Reference: LY2228820(862505-00-8)
    11. EPA Substance Registry System: LY2228820(862505-00-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 862505-00-8(Hazardous Substances Data)

862505-00-8 Usage

Uses

Used in Pharmaceutical Industry:
LY2228820 is used as an anti-inflammatory agent for its potential to inhibit the activation and production of pro-inflammatory cytokines, such as TNF-alpha and IL-6. This makes it a promising treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
Used in Preclinical and Early Clinical Studies:
LY2228820 is used as a research compound to evaluate its therapeutic potential in treating various inflammatory conditions. Its ability to inhibit p38α and p38β MAPK isoforms has shown promise in reducing inflammation and alleviating symptoms associated with inflammatory diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 862505-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,2,5,0 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 862505-00:
(8*8)+(7*6)+(6*2)+(5*5)+(4*0)+(3*5)+(2*0)+(1*0)=158
158 % 10 = 8
So 862505-00-8 is a valid CAS Registry Number.

862505-00-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine

1.2 Other means of identification

Product number -
Other names UNII-73I34XW4HD

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:862505-00-8 SDS

862505-00-8Downstream Products

862505-00-8Relevant articles and documents

KINASE INHIBITORS

-

Page/Page column 49, (2010/02/13)

The present invention provides kinase inhibitors of Formula I.

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