- Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis
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Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species.
- Kuroyanagi, Jun-Ichi,Kanai, Kazuo,Sugimoto, Yuuichi,Fujisawa, Tetsunori,Morita, Chikanori,Suzuki, Takashi,Kawakami, Katsuhiro,Takemura, Makoto
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experimental part
p. 5845 - 5854
(2010/10/01)
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- FUNGICIDAL HETEROCYCLIC COMPOUNDS
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A compound which can specifically or selectively expresses an antifungal activity with a broad spectrum, based on the functional mechanism of 1,6-β-glucan synthesis inhibition, is provided, and an antifungal agent which comprises such a compound, a salt thereof or a solvate thereof is provided. A compound represented by the following formula (I), a salt thereof or a solvate thereof.
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Page/Page column 46
(2010/11/24)
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