863605-34-9

Basic information

• Product Name: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE
• Synonyms: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE;1H-Pyrazole, 4-bromo-3-(4-fluorophenyl)-1-methyl-;EOS-62021
• CAS NO: 863605-34-9
• Molecular Formula: C₁₀H₈BrFN₂
• Molecular Weight: 255.0863232
• Mol File: 863605-34-9.mol

Chemical Properties

• Boiling Point: 315.3±27.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: -0.49±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(863605-34-9)
• EPA Substance Registry System: 4-BROMO-3-(4-FLUOROPHENYL)-1-METHYL-1H-PYRAZOLE(863605-34-9)

Safety Data

• Hazardous Substances Data: 863605-34-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole is used as a chemical intermediate for the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Industry:
In the chemical industry, 4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole is utilized as a building block for the creation of a variety of organic compounds, contributing to the advancement of chemical research and product development.
Used in Agrochemical Development:
4-Bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole may also be employed in the development of agrochemicals, where its properties could be harnessed to create new products for agricultural applications, such as pesticides or herbicides.
Safety Precautions:
As with any chemical compound, it is essential to follow proper handling and safety procedures when working with 4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole to ensure the safety of individuals and the environment.

Upstream product

• 863605-35-0 3-(4'-fluorophenyl)-1-methylpyrazole 
• 75175-77-8 3-(dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 474706-36-0 4-bromo-3-(4-fluorophenyl)-1H-pyrazole 
• 74-88-4 methyl iodide 
• 154258-82-9 3-(4-fluorophenyl)-1H-pyrazole 

Downstream Products

• 1616235-69-8 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine 
• 1616235-11-0 6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine 
• 1616235-12-1 1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea 
• 1616235-13-2 benzyl 6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-ylcarbamate 
• 1616235-14-3 3-bromo-6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-N-(pyrimidin-2-yl)imidazo[1,2-b]pyridazin-2-amine 
• 1616235-42-7 6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine 
• 1616233-24-9 N-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)isonicotinamide 
• 1616235-43-8 N-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide 

Relevant articles and documents

Synthesis of novel fluorophenylpyrazole-picolinamide derivatives and determination of their anticancer activity

A series of fluorophenylpyrazole-picolinamide derivatives were synthesized in high yields using a cross-coupling reaction catalyzed by in situ formed palladium-N-heterocyclic carbenes (Pd-NHCs). The synthesized novel derivatives were evaluated for in vitro anticancer activity against a panel of four human tumor cell lines, HeLa (cervical), A-549 (lung), MCF-7 (breast), and IMR-32 (neuroblastoma). Four compounds, 11c, 11e, 11j, and 11k, showed growth inhibition (low μM) comparable with the standard drug cisplatin, providing a preliminary structure–activity relationship for the series. The present procedure is operationally simple and works with a wide range of substrates and may thus be useful in further compound optimization.

TGF Beta RECEPTOR ANTAGONISTS

The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

PYRAZOLE SUBSTITUTED IMIDAZOPYRAZINES AS CASEIN KINASE 1 D/E INHIBITORS

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The compounds of Formula (I) inhibit protein kinase activity thereby making them useful as anticancer agents.

KINASE INHIBITORS

ABSTRACT The present invention provides kinase inhibitors of Formula I: .