75175-77-8

Basic information

• Product Name: 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE
• Synonyms: 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE;2-Propen-1-one, 3-(diMethylaMino)-1-(4-fluorophenyl)-;3-(Dimethylamino)-1-(4-fluorophenyl)prop-2-en-1-one;(E)-3-dimethylamino-1-(4-fluorophenyl)prop-2-en-1-one;2-Propen-1-one, 1-(4-fluorophenyl)-3-dimethylamino-;Propenone, 1-(4-fluorophenyl)-3-dimethylamino-;3-(4-Fluorophenyl)-N,N-dimethylacrylamide
• CAS NO: 75175-77-8
• Molecular Formula: C₁₁H₁₂FNO
• Molecular Weight: 193.22
• Mol File: 75175-77-8.mol
• Article Data: 33

Chemical Properties

• Melting Point: 84-86°
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE(75175-77-8)
• EPA Substance Registry System: 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE(75175-77-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 75175-77-8(Hazardous Substances Data)

Usage

Description

3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE, also known as 4-fluoro PVP, is a synthetic chemical compound that is a derivative of the stimulant drug alpha-PVP. It is classified as a cathinone and is known for its stimulant and psychoactive effects, which can produce feelings of euphoria, increased energy, and heightened alertness. However, it has a high potential for abuse and addiction, leading to legal restrictions in many countries.

Uses

Used in Pharmaceutical Research:
3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE is used as a research chemical for studying the effects and mechanisms of action of stimulant drugs. Its structural and functional similarities to other cathinones make it a valuable tool in understanding the pharmacology of these substances.
Used in Forensic Analysis:
In the field of forensic analysis, 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE is used for the identification and analysis of designer drugs. Its detection in seized materials can provide valuable information about the presence of controlled substances and their distribution.
Used in Controlled Substance Regulation:
Due to its high potential for abuse and addiction, 3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)-2-PROPEN-1-ONE is subject to legal restrictions and is regulated as a controlled substance in many countries. Its production, sale, and possession are monitored and controlled to prevent misuse and protect public health.

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 701-47-3 1-(4-fluorophenyl)propanol 
• 7542-64-5 α,α-Dibromo-4'-fluoroacetophenone 
• 5157-58-4 2,2-dichloro-1-(4-fluorophenyl)-ethan-1-one 
• 68049-19-4 4-(4-fluorophenyl)pyrimidine 

Relevant articles and documents

Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones

We have developed a method to synthesize α,α-dihaloketones under electrochemical conditions. In this reaction, the Cl- or Br- is oxidized to Cl2 or Br2 at the anode, which undergoes two-step addition reactions with the N,N-dimethyl enaminone, and finally breaks C[dbnd]C of the N,N-dimethyl enaminone to generate α,α-dihaloketones. The electrosynthesis reaction can be conveniently carried out in an undivided electrolytic cell at room temperature. In addition, various functional groups are compatible with this green protocol which can be applied simultaneously to the gram scale without significantly lower yield.

SUBSTITUTED ARYL COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF

The present application relates to a substituted aryl compound or a pharmaceutically acceptable salt, a stereoisomer, a polymorph, a solvate, a N-oxide, an isotope-labeled compound, a metabolite or a prodrug thereof, and a preparation method therefor and use thereof, also relates to a pharmaceutical composition containing the compound and a therapeutic use thereof. The compound or a pharmaceutical composition thereof can inhibit the activity of adenosine A2a receptor, and can be used for treating or preventing a disease related to adenosine A2a receptor, especially for treating a tumor.

An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes asC4units

An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standardC4units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavage of the enaminone and insertion of a newC(sp2) source with the formation of two C-C single bonds. A broad range of substrates can be used to synthesize the corresponding 1,3-dienes under very mild reaction conditions, including low catalyst-loading, ambient temperature, and a neutral reaction solvent.