864738-31-8

Basic information

• Product Name: 8-bromoisoquinolin-4-ol
• Synonyms: 8-bromoisoquinolin-4-ol;8-Bromo-4-isoquinolinol
• CAS NO: 864738-31-8
• Molecular Formula: C9H6BrNO
• Molecular Weight: 224.05404
• Mol File: 864738-31-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-bromoisoquinolin-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 8-bromoisoquinolin-4-ol(864738-31-8)
• EPA Substance Registry System: 8-bromoisoquinolin-4-ol(864738-31-8)

Safety Data

• Hazardous Substances Data: 864738-31-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
8-bromoisoquinolin-4-ol is used as a GABAC receptor agonist for its potential role in modulating the activity of the GABAC receptor, which may have therapeutic applications in the treatment of neurological disorders.
Used in Anticancer Applications:
8-bromoisoquinolin-4-ol is used as a potential anti-cancer agent for its cytotoxic effects on certain cancer cell lines, suggesting that it may have potential in the development of new cancer therapies.
Used in Synthetic Chemistry:
8-bromoisoquinolin-4-ol is used as a building block in the synthesis of various organic molecules due to its versatile reactivity, making it a valuable component in the creation of new chemical compounds for various applications.

Upstream product

• 864738-28-3 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycine 
• 852358-46-4 methyl 2-[N-(2-bromobenzyl)amino]acetate 
• 6630-33-7 ortho-bromobenzaldehyde 
• 864738-29-4 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycyl chloride 
• 864738-30-7 8-bromo-2-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-isoquinolin-4-one 
• 864738-27-2 methyl N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycinate 

Relevant articles and documents

Synthesis method of 4-hydroxy-8-bromoisoquinoline

The invention discloses a synthesis method of 4-hydroxy-8-bromoisoquinoline. The method comprises the following steps: mixing bromobenzylamine with a toluene solution, then adding p-toluenesulfonic acid and glyoxylic acid, heating, refluxing, dehydrating

Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions

New 8-(het)aryltetrahydroisoquinolines (10-14), 8- aryltetrahydroisoquinolin-4-ols (15,16), and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from