852358-46-4

Upstream product

• 616-34-2 methoxycarbonylmethylamine 
• 6630-33-7 ortho-bromobenzaldehyde 
• 5680-79-5 glycine ethyl ester hydrochloride 

Downstream Products

• 1026576-68-0 [(2-bromo-benzyl)-methyl-amino]-acetic acid methyl ester 
• 864738-27-2 methyl N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycinate 
• 1245604-36-7 methyl 2-[N-benzyl-N-(2-bromobenzyl)amino]acetate 
• 503034-62-6 L-N-2-bromobenzyl-N-methyl-Cly-N'-3-(trimethylsilyl)propargyl-Gly-OMe 
• 76304-20-6 8-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 864738-37-4 8-(3,4-dimethoxyphenyl)-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline 
• 864738-28-3 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycine 
• 864738-29-4 N-(2-bromobenzyl)-N-[(4-methylphenyl)sulfonyl]glycyl chloride 
• 864738-30-7 8-bromo-2-[(4-methylphenyl)sulfonyl]-2,3-dihydro-1H-isoquinolin-4-one 
• 864738-32-9 8-bromo-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinolin-4-ol 
• 864738-33-0 8-bromo-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Selective synthesis of either isoindole- or isoindoline-1-carboxylic acid esters by Pd(0)-catalyzed enolate arylation

Figure presented. Two efficient palladium-catalyzed intramolecular α-arylation reactions of α-amino acid esters have been developed that allow either 1-isoindolecarboxylic acid esters or the corresponding isoindolines to be selectively synthesized simply by a slight change of reaction conditions.

Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions

New 8-(het)aryltetrahydroisoquinolines (10-14), 8- aryltetrahydroisoquinolin-4-ols (15,16), and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from

Application of peptidyl radicals into a new radical cascade leading to unsaturated γ-lactams

Radical cyclization of dipeptides 1a-h proceeds smoothly to give five- and seven-membered rings in good to moderate total yields using Stork's catalytic tin hydride method. A radical is generated on a protecting group and translocated to the peptide moiety. Following a cyclization reaction, the vinyl radical can abstract hydrogen from a benzyl group on an amine, which results in elimination of the protected amine group. Encouraging results have notably been obtained with amino acids other than glycine.