cas 86499-69-6, (2-Oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-carbaMicacidtert-butylester | Articles data ｜lookchem

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86499-69-6

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Articles about 86499-69-6Total 6 be found

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2-ALKOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZAZEPINES, THE PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING THE SAME
The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzodiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds, and to intermediate precursors to such compounds.
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Page/Page column 4-5

(2009/04/24)

Novel 3,4-Dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a
The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.
Rosauer, Keith G.,Ogawa, Anthony K.,Willoughby, Chris A.,Ellsworth, Kenneth P.,Geissler, Wayne M.,Myers, Robert W.,Deng, Qiaolin,Chapman, Kevin T.,Harris, Georgianna,Moller, David E.
p. 4385 - 4388
(2007/10/03)

Lactam inhibitors of factor Xa and method
Lactam inhibitors are provided which have the structure including pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; and and R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, 1011 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.
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(2008/06/13)

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.
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(2008/06/13)

3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
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(2008/06/13)

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.
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(2008/06/13)

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Chemical Properties

Boiling Point: 472.5±44.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
Storage Temp.:2-8°C
PKA: 11.34±0.20(Predicted)
PSA: 67.43000
LogP: 2.99350

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