- Oxidation of Primary Alcohols and Aldehydes to Carboxylic Acids via Hydrogen Atom Transfer
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The oxidation of primary alcohols and aldehydes to the corresponding carboxylic acids is a fundamental reaction in organic synthesis. In this paper, we report a new chemoselective process for the oxidation of primary alcohols and aldehydes. This metal-free reaction features a new oxidant, an easy to handle procedure, high isolated yields, and good to excellent functional group tolerance even in the presence of vulnerable secondary alcohols and tert-butanesulfinamides.
- Tan, Wen-Yun,Lu, Yi,Zhao, Jing-Feng,Chen, Wen,Zhang, Hongbin
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supporting information
p. 6648 - 6653
(2021/09/08)
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- Synthesis method of 2-(4-ethoxyphenyl)-2-methyl propanol
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The invention discloses a synthetic method of 2-(4-ethoxyphenyl)-2-methyl propanol, and belongs to the technical field of organic synthesis. The method comprises the following steps: performing isobutyryl chloride Friedel-Crafts acylation by taking cheap phenethyl ether as a raw material and ionic liquid as a reaction solvent, extracting and separating methyl tert-butyl ether after reaction, washing and drying an ether phase, recovering the ether phase, distilling and purifying to obtain a product, adding tert-butyl ether, adding metered liquid bromine for bromination, washing after bromination, treating and crystallizing, adding petroleum ether, refluxing, dehydrating and condensing with neopentyl glycol under the catalytic action of p-toluenesulfonic acid to obtain a condensation compound; and carrying out high-temperature transposition on the condensation compound and a catalyst zinc salt in a solvent, directly hydrolyzing with an alkaline solution, and finally reducing under the action of sodium borohydride and aluminum trichloride to obtain the 2-(4-ethoxyphenyl)-2-methyl propanol. The method is high in yield, safe, environmentally friendly and easy to operate, a small amount of aluminum trichloride is supplemented into the ionic liquid and then reused, and neopentyl glycol regenerated through the hydrolysis reaction can also be recycled.
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Paragraph 0007; 0029
(2021/05/01)
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