- Facile and efficient generation of quinolone amides from esters using aluminum chloride
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Quinolone esters are readily converted into the corresponding amides using aluminum chloride at room temperature in excellent yields and purities. The method is both general and scalable to multi-kilogram quantities.
- Schwaebe, Michael K.,Ryckman, David M.,Nagasawa, Johnny Y.,Pierre, Fabrice,Vialettes, Anne,Haddach, Mustapha
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scheme or table
p. 1096 - 1100
(2011/03/22)
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- Novel benzothiazole compounds and methods of use thereof
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The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with formula NHR1R2, and a Lewis acid having formula MLn, wherein L is a halogen atom or an organic radical, n is 3-5, and M is a group III elemental atom, a group IV elemental atom, As, Sb, V or Fe, wherein A, B, V, X, Z, W, R1, R2, R5, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8 are substituents. Z4, Z5, Z6, Z7, and Z8 are substituents.
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Page/Page column 6; 12
(2010/10/20)
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