865311-47-3 Usage
General Description
CX-3543, also known as Quarfloxin, is a small molecule that targets and binds to G-quadruplex DNA structures, leading to an inhibition of ribosomal RNA synthesis and disruption of nucleolar function. This disruption ultimately results in the activation of apoptotic pathways and cell death in cancer cells. CX-3543 has shown promising anti-tumor activity in preclinical studies and early phase clinical trials, particularly in solid tumors such as small cell lung cancer and neuroendocrine tumors. Additionally, it has demonstrated synergistic effects with other anti-cancer agents, making it a potential candidate for combination therapy in the treatment of various cancer types. However, further research and clinical trials are needed to fully understand its potential as a therapeutic agent.
Check Digit Verification of cas no
The CAS Registry Mumber 865311-47-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,1 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 865311-47:
(8*8)+(7*6)+(6*5)+(5*3)+(4*1)+(3*1)+(2*4)+(1*7)=173
173 % 10 = 3
So 865311-47-3 is a valid CAS Registry Number.
865311-47-3Relevant articles and documents
Facile and efficient generation of quinolone amides from esters using aluminum chloride
Schwaebe, Michael K.,Ryckman, David M.,Nagasawa, Johnny Y.,Pierre, Fabrice,Vialettes, Anne,Haddach, Mustapha
scheme or table, p. 1096 - 1100 (2011/03/22)
Quinolone esters are readily converted into the corresponding amides using aluminum chloride at room temperature in excellent yields and purities. The method is both general and scalable to multi-kilogram quantities.
