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CAS

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865759-10-0

Alogliptin Related Compound 26, also known as N-Desmethyl,N-2(2-cyanobenzyl) Alogliptin, is an impurity of Alogliptin (A575425). Alogliptin is an oral antihyperglycemic agent that acts as a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Alogliptin Related Compound 26 plays a significant role in the development and manufacturing process of antidiabetic agents.

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  • 865759-10-0 Structure

  • Basic information

    1. Product Name: Alogliptin Related Compound 26
    2. Synonyms: (R)-2,2'-((6-(3-aminopiperidin-1-yl)-2,4-dioxopyrimidine-1,3(2H,4H)-diyl)bis(methylene))dibenzonitrile;(R)-2,2'-((6-(3-aminopiperidin-1-yl)-2,4-ioxopyrimidine-1,3(2H,4H)-diyl)bis(methylene))dibenzonitrile
    3. CAS NO:865759-10-0
    4. Molecular Formula: C25H24N6O2
    5. Molecular Weight: 440.5
    6. EINECS: -0
    7. Product Categories: N/A
    8. Mol File: 865759-10-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 651.9±65.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.37±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 9.89±0.20(Predicted)
    10. CAS DataBase Reference: Alogliptin Related Compound 26(CAS DataBase Reference)
    11. NIST Chemistry Reference: Alogliptin Related Compound 26(865759-10-0)
    12. EPA Substance Registry System: Alogliptin Related Compound 26(865759-10-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 865759-10-0(Hazardous Substances Data)

865759-10-0 Usage

Uses

Used in Pharmaceutical Industry:
Alogliptin Related Compound 26 is used as an impurity in the development and manufacturing of Alogliptin, an oral antihyperglycemic agent. It is essential to monitor and control the presence of this impurity to ensure the safety, efficacy, and quality of the final antidiabetic drug product.
Alogliptin Related Compound 26 is used as a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4) for the management of type 2 diabetes. It helps in controlling blood sugar levels by increasing the levels of insulin and decreasing the levels of glucagon, thus improving glycemic control in patients with diabetes.

Check Digit Verification of cas no

The CAS Registry Mumber 865759-10-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,7,5 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 865759-10:
(8*8)+(7*6)+(6*5)+(5*7)+(4*5)+(3*9)+(2*1)+(1*0)=220
220 % 10 = 0
So 865759-10-0 is a valid CAS Registry Number.

865759-10-0Upstream product

865759-10-0Downstream Products

865759-10-0Relevant articles and documents

DIPEPTIDYL PEPTIDASE INHIBITORS

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Page/Page column 27, (2009/12/02)

Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.

Dipeptidyl peptidase inhibitors

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Page/Page column 49, (2008/06/13)

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising Formula I: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C=NR9; and each R1, R2, R3, R4 and R9 are as defined herein.

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