- Sodium amalgam mediated desulfonylative reduction of α-functionalized β-ketosulfones
-
Sodium amalgam mediated desulfonylative reduction of β-ketosulfones in MeOH at rt affords alcohols in good yields via radical desulfonylation of β-ketosulfones and sequential Bouveault-Blanc reduction of the resulting ketones.
- Chan, Chieh-Kai,Huang, Yi-Hsuan,Chang, Meng-Yang
-
p. 5521 - 5529
(2016/08/04)
-
- Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N- methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors
-
The present work describes a series of novel chiral amines that potently inhibit the in vitro reuptake of serotonin, norepinephrine and dopamine (triple reuptake inhibitors) and were active in vivo in a mouse model predictive of antidepressant like activi
- Shao, Liming,Wang, Fengjiang,Malcolm, Scott C.,Ma, Jianguo,Hewitt, Michael C.,Campbell, Una C.,Bush, Larry R.,Spicer, Nancy A.,Engel, Sharon R.,Saraswat, Lakshmi D.,Hardy, Larry W.,Koch, Patrick,Schreiber, Rudy,Spear, Kerry L.,Varney, Mark A.
-
experimental part
p. 663 - 676
(2011/03/17)
-
- Iodine(III)-promoted ring contraction of 1,2-dihydronaphthalenes: A diastereoselective total synthesis of (±)-indatraline
-
Equation presented A new approach for the synthesis of (±)- indatraline, which is a 3-phenyl-1-indanamine that displays several biological activities, is described. The strategy features as the key step a diastereoselective ring contraction of a 1,2-dihydronaphthalene promoted by Phl(OTs)OH, to construct the indan ring system. The oxidative rearrangement of other 1,2-dihydronaphthalenes was also investigated, generalizing this method to obtain indans.
- Silva Jr., Luiz F.,Siqueira, Fernanda A.,Pedrozo, Eliane C.,Vieira, Fabiana Y. M.,Doriguetto, Antonio C.
-
p. 1433 - 1436
(2008/02/02)
-
- Efficient kinetic resolution in hydroboration of 1,2-dihydronaphthalenes
-
1-Substituted 1,2-dihydronaphthalenes undergo kinetic resolution during asymmetric hydroboration with Rh-QUINAP complexes.
- Maeda, Kenji,Brown, John M.
-
p. 310 - 311
(2007/10/03)
-