- Synthesis and tranquillizing effect of new 1,4-benzoxazepines
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A SERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4-benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the corresponding 1,4-benzoxazepine-5(4H)-thiones. N-alkylation of the 1,4-benzoxazepin-5(4H)-ones and S-alkylation of the 1,4-benzoxazepine-5(4H)-thiones were described. Some of the new compounds were subjected to preliminary screening for their tranquilizing effect.
- Botros,Naguib,Osman
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p. 565 - 578
(2013/05/08)
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- Synthesis and tranquillizing effect of new 1,4- benzoxazepines
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A SERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4- benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the
- Botios,Naguib,Osman
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p. 565 - 578
(2016/07/06)
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