86629-72-3Relevant articles and documents
Synthesis and Biological Activity of 4a,4"-Disubstituted Avermectins
Jones, Todd K.,Chu, Lin,Mrozik, Helmut,Slayton, Lyndia,Rafalko, Bryan,et al.
, p. 1786 - 1790 (2007/10/02)
Allylic oxidation of avermectin B1 and C4-substituted avermectin B1 analogues at C4a followed by derivatization of the C4a oxygen provides compounds that have an improved safety profile, as judged bu mouse LDsu
The C4-Exo Methylene Isomer of Avermectin B1a: Synthesis via an Allylic Radical and Bioactivity
Fraser-Reid, Bert,Lopez, J. Cristobal,Faghih, Ramin
, p. 6763 - 6768 (2007/10/02)
Avermectin B1aΔ4,4a, 2, has been obtained from avermectin B1a, 1, and its bioactivity evaluated.The key step of the transformation is the reduction of an intermediate allylic radical with nBu3SnH.