Preparation of isoxazol(in)yl substituted selenides and their further deselenenylation reaction to synthesize 3,5-disubstituted isoxazoles
We report a mild 1,3-dipolar cycloaddition protocol for the preparation of 3-aryl-5-phenylselenomethyl isoxazoles and isoxazolines regioselectively. The former was further reacted with LDA and electrophilic substrates followed by selenoxide syn-eliminatio
The invention discloses a synthesis method for an iodoisoxazoline compound shown as formula (II). The method includes: dissolving ketoxime shown as formula (I), an iodine source and an oxidant mixedlyin a solvent, carrying out reaction for 7-15h at 25DEG
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Paragraph 0070-0073
(2019/02/13)
A novel cleavage for polystyrene-supported selenium resins: An efficient route to 3,5-disubstituted isoxazolines and their derivatives
We report here a novel cleavage method for polystyrene-supported selenium resin using CH3I-NaI under mild conditions to prepare 3,5-disubstituted isoxazolines. The polymer selenium resins can be reused without further transformation. Georg Thie