867267-24-1

Basic information

• Product Name: 2,5-Dimethoxy Pyridine
• Synonyms: 2,5-Dimethoxypyridine
• CAS NO: 867267-24-1
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• Mol File: 867267-24-1.mol

Chemical Properties

• Boiling Point: 203.5±20.0℃ (760 Torr)
• Flash Point: 73.2±12.0℃
• Appearance: /
• Density: 1.064±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 0.70±0.10(Predicted)
• CAS DataBase Reference: 2,5-Dimethoxy Pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethoxy Pyridine(867267-24-1)
• EPA Substance Registry System: 2,5-Dimethoxy Pyridine(867267-24-1)

Safety Data

• Hazardous Substances Data: 867267-24-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Dimethoxy Pyridine is used as a reactant for the regioselective preparation of trioxopyrrolopyridines and functionalized azaindoles. These compounds are of significant interest in the pharmaceutical industry due to their potential applications as therapeutic agents and their role in the development of novel drug candidates with improved pharmacological properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,5-Dimethoxy Pyridine serves as a versatile building block for the creation of a wide range of complex organic molecules. Its unique reactivity and functional groups make it an ideal candidate for use in the synthesis of various heterocyclic compounds, which are important in many areas of chemistry, including materials science, agrochemistry, and medicinal chemistry.
Used in Research and Development:
2,5-Dimethoxy Pyridine is also utilized in research and development settings, where it can be employed to study the reactivity and properties of pyridine-based compounds. This knowledge can be applied to the design and synthesis of new molecules with specific functions and applications, further expanding the potential uses of 2,5-Dimethoxy Pyridine in various industries.

Upstream product

• 51834-97-0 6-methoxypyridine-3-ol 
• 74-88-4 methyl iodide 

Downstream Products

• 1630193-77-9 (2,5-dimethoxypyridin-4-yl)boronic acid 

Relevant articles and documents

Solvent-dependent oxidations of 5- and 6-azaindoles to trioxopyrrolopyridines and functionalised azaindoles

A regioselective synthesis of 4,7-dimethoxy 5- and 6-azaindoles 2 has been achieved, based on the appropriate choice of ortho-directing or ortho-repulsing groups in the formylation of a pyridine ring. Studies on the regioselectivity of the formylation step and on the preparation of azidoacrylate intermediates 4 are described in this paper. The reactivity of the 5- and 6-azaindole structures towards BBr3-mediated selective monodemethylation and oxidative demethylation reactions were also investigated. The regioselectivity of the deprotection was confirmed using a chemical approach. Oxidation reactions were then carried out on either dimethoxy- or hydroxymethoxyazaindoles, in different solvents, using [bis(trifluoroacetoxy)iodo]benzene. In acetonitrile-water, trioxopyrrolopyridines 12 were obtained, whereas the formation of functionalised azaindoles 17 was observed in acetonitrile-methanol. The tautomeric structure of the trioxopyrrolopyridines was proved by X-ray diffraction analysis. The Royal Society of Chemistry.

A regioselective route to 5- and 6-azaindoles

The synthesis of 4,7-dimethoxy 5- and 6-azaindoles, a structural unit that is present in recently developed anti-HIV-1 agents, was achieved in a regioselective manner. The developed strategy is based on the appropriate choice of a protecting group during a lithium-mediated formylation step, followed by thermal cyclization of azidoacrylates. Georg Thieme Verlag Stuttgart.