2,5-Dimethoxypyridine

Base Information

• Chemical Name: 2,5-Dimethoxypyridine
• CAS No.: 867267-24-1
• Molecular Formula: C7H9 N O2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• European Community (EC) Number: 800-641-3
• DSSTox Substance ID: DTXSID20540655
• Wikidata: Q72468475
• Mol file: 867267-24-1.mol

Synonyms:2,5-DIMETHOXYPYRIDINE;867267-24-1;2,5-Dimethoxy Pyridine;MFCD12546620;SCHEMBL3816388;AMY6214;DTXSID20540655;BCP25365;AKOS006346085;DS-7366;PB43623;AC-33324;SY037979;CS-0044152;EN300-243407;I11454

Chemical Property of 2,5-Dimethoxypyridine

Chemical Property:

• Boiling Point: 203.5±20.0℃ (760 Torr)
• PKA: 0.70±0.10(Predicted)
• Flash Point: 73.2±12.0℃
• PSA: 31.35000
• Density: 1.064±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.09880
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98%, ^*data from raw suppliers

2,5-Dimethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CN=C(C=C1)OC
• Uses: 2,5-Dimethoxypyridine is used as a reactant in the regioselective preparation of trioxopyrrolopyridines / functionalized azaindoles.

Technology Process of 2,5-Dimethoxypyridine

There total 1 articles about 2,5-Dimethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

6-methoxypyridine-3-ol (51834-97-0) + methyl iodide (74-88-4) → 2,5-dimethoxypyridine (867267-24-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;

DOI:10.1055/s-2005-871946

Reference yield: 64.0%

2,5-dimethoxypyridine (867267-24-1) + 5-decyne (1942-46-7) → (E)-4-(dec-5-en-5-yl)-2,5-dimethoxypyridine

Guidance literature:

With cobalt(III) acetylacetonate; 1,3-bis-(diphenylphosphino)propane; trimethylaluminum; In n-heptane; toluene; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jacs.0c06412

Reference yield: 55.0%

2,5-dimethoxypyridine (867267-24-1) + aniline (62-53-3) → 5-methoxy-N-phenylpyridin-2-amine (1570075-46-5)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.9b01711

upstream raw materials:

6-methoxypyridine-3-ol

methyl iodide

Downstream raw materials:

2,5-dimethoxy-pyridine-4-carbaldehyde

2,5-dimethoxy-pyridine-3-carbaldehyde