- Substituted diazabicycloakane derivatives
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Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.
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Page/Page column 32
(2010/02/11)
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- Amino-substituted tricyclic derivatives and methods of use
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Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y1 and Y2 form various tricyclic cores, Xa and Xb are C, CH, or N, as defined herein, and Rx is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.
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Page/Page column 62
(2010/02/14)
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- 8-vinyl- and 9-ethinyl-quinolone-carboxylic acids
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The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.
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- Condensed diazepinones and medicaments containing these compounds
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Condensed diazepinones of general formula I STR1 in which ]B represents one of the divalent groups STR2 X is a =CH-- group or a nitrogen atom, R represents a lower alkyl radical, which may optionally be further substituted by a phenyl optionally carrying halogen, methyl or methoxy, R4 and R5 represent hydrogen, halogen or lower alkyl, R6 is hydrogen, chlorine or methyl, R7 and R8 denote lower alkyl, R8 also additionally denotes halogen, and m, n, o and p represent the numbers 0, 1, 2 or 3 with the following limitations: the sum of m+n and the sum of o+p each denote the numbers 1, 2 or 3, the sum of n+o and the sum of m+p each denote the numbers 1, 2, 3, 4 or 5, wherein, however, the sum of m+n+o+p must always be greater than 2, and A1, A2, A3 and A4 denote hydrogen, or, for the case where m, n, o and p each denote the number 1, A1 and A2 together or A3 and A4 together represent an ethylene bridge, are suitable for the treatment of cholinergically induced spasms and motility disorders of the gastrointestinal tract and in the region of the evacuating bile ducts, for the symptomatic treatment of cystitis and of spasms from urelithiasis, for the treatment of relative incontinence, for the symptomatic treatment of bronchial asthma and bronchitis, and for the treatment of ischaemic heart diseases. The compounds are characterized by good selectivity.
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- Synthesis and Carbon-13 NMR Study of 2-Benzyl, 2-Methyl, 2-Aryloctahydropyrrolopyrroles and the 1,2,3,5-Tetrahydropyrrolopyrrole Ring System
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2-Benzyl, 2-phenyl, 2-(3-methoxyphenyl) and 2-(3-trifluoromethylphenyl)octahydropyrrolopyrrole (9a, 9b, 9c and 9d, respectively) were prepared in five steps from 1-benzylpyrrole-3,4-dicarboxylic acid (2). 2-Methyloctahydropyrrolopyrrole (9'a
- Ohnmacht, Cyrus J.,Draper, Clyde W.,Dedinas, Robert F.,Loftus, Philip,Wong, J. J.
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p. 321 - 329
(2007/10/02)
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