868364-63-0

Usage

Uses

Used in Pharmaceutical Synthesis:
(1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid is utilized as an intermediate in the synthesis of pharmaceuticals. Its unique chemical structure allows it to be a key building block in the creation of new drugs, potentially leading to the development of novel treatments for various diseases and conditions.
Used in Agrochemical Production:
(1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid also serves as an intermediate in the synthesis of agrochemicals. Its application in this field can contribute to the development of new pesticides, herbicides, or other agricultural products that can improve crop yields and protect plants from pests and diseases.
Used in Medicinal Chemistry Research:
(1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid has potential applications in the field of medicinal chemistry due to its unique chemical structure and reactivity. Researchers can use (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid to explore new chemical reactions and pathways, which may lead to the discovery of innovative drugs and therapeutic agents.
Used in Drug Development:
As a building block for the synthesis of various bioactive compounds, (1R,2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid plays a crucial role in drug development. Its potential biological activity and versatility in chemical reactions make it a promising candidate for the creation of new pharmaceuticals with improved efficacy and safety profiles.

Upstream product

• 951173-22-1 (+/-)-cis-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid 
• 1333084-20-0 (4S,5R)-N-[(1R,2S)-2-(t-butyloxycarbonylamino)cyclobutanecarbonyl]-4-methyl-5-phenyl-1,3-oxazolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 402848-96-8 tert-butyl 2,4-dioxo-1,2,3,4-tetrahydropyrimidine-1-carboxylate 
• 88335-88-0 (1S,2R)-cis-2-methoxycarbonyl-cyclobutane-1-carboxylic acid 
• 221158-95-8 (1R,2S)-cis-2-amino-cyclobutane-1-carboxylic acid 
• 868364-62-9 methyl (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylate 

Downstream Products

• 868364-62-9 methyl (-)-(1R,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylate 
• 951173-22-1 (-)-(1S,2S)-2-[(tert-butyloxycarbonyl)amino]cyclobutanecarboxylic acid 
• 1374222-84-0 benzyl tert-butyl (1S,2S)-cyclobutane-1,2-diylbiscarbamate 
• 1374222-18-0 tert-butyl N-[(1S,2S)-2-aminocyclobutyl]carbamate 
• 1442447-40-6 (1R,2S)-methyl 2-((S)-1-(t-butyloxycarbonylamino)azetidine-2-carboxamido)cyclobutane carboxylate 

Relevant academic research and scientific papers

A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids

The synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids has been refined to improve both the efficiency and the simplicity. These improvements provide a shorter and easier access to the racemic cis-cyclobutane β-amino acid core. Derivatization of this material with a chiral non-racemic oxazolidin-2-one allows easy diastereoisomeric separation and presents the advantage of allowing the non-destructive cleavage of the chiral auxiliary either by hydrolysis or by ammonolysis, thus providing an efficacious access to N-protected derivatives of all four stereoisomers of Boc-2-aminocyclobutanecarboxylic acid.

Stereoselective synthesis of all stereoisomers of orthogonally protected cyclobutane-1,2-diamine and some chemoselective transformations

The four stereoisomers of protected cyclobutane-1,2-diamine have been prepared in an enantio- and diastereocontrolled manner through stereodivergent synthetic routes starting from a half-ester as a common chiral precursor. Orthogonal protection allows the

[2+2] Photocycloadditions with chiral uracil derivatives: Access to all four stereoisomers of 2-aminocyclobutanecarboxylic acid

Starting from a single, chiral, bicyclic derivative of uracil, all four stereoisomers of 2-aminocyclobutanecarboxylic acid have been prepared in enantiomerically pure form, using a synthetic sequence which begins with a key photochemical [2+2] cycloaddition reaction and includes a practical cis to trans β-amino acid isomerisation procedure. Georg Thieme Verlag Stuttgart.

(+)- and (-)-2-aminocyclobutane-1-carboxylic acids and their incorporation into highly rigid β-peptides: Stereoselective synthesis and a structural study

Several derivatives of (+)- and (-)-2-aminocyclobutane-1-carboxylic acid, 1, have been prepared through enantiodivergent synthetic sequences. The stereoselective synthesis of free amino acid (+)-1 has been achieved, and this product has been fully charact