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CAS

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868692-62-0

N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide, also known as BAY 43-9006, is a chemical compound with potential anti-cancer properties. It is a kinase inhibitor that specifically targets and inhibits certain enzymes involved in cell growth and proliferation, making it a promising candidate for the treatment of various types of cancer.
Used in Pharmaceutical Industry:
N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide is used as an anti-cancer agent for the treatment of advanced renal cell carcinoma and other solid tumors. Its mechanism of action involves the inhibition of both the Raf/MEK/ERK signaling pathway and the VEGFR/PDGFR signaling pathways, which are known to be dysregulated in cancer cells. BAY 43-9006 has been approved for use in the treatment of advanced kidney cancer and has shown potential for the treatment of other solid tumors as well.

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  • 868692-62-0 Structure

  • Basic information

    1. Product Name: N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide
    2. Synonyms: N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide;4-Cyano-2-iodo-N-Methylsulfonyl-5-(trifluoroMethyl)aniline;N-(4-CYANO-2-IODO-5-(TRIFLUOROMETHYL)PHENYL)METHANESULFONAMIDE（WS204096）
    3. CAS NO:868692-62-0
    4. Molecular Formula: C9H6F3IN2O2S
    5. Molecular Weight: 390.1208196
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 868692-62-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide(868692-62-0)
    11. EPA Substance Registry System: N-(4-Cyano-2-iodo-5-(trifluoromethyl)-phenyl)methanesulfonamide(868692-62-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 868692-62-0(Hazardous Substances Data)

868692-62-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 868692-62-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,8,6,9 and 2 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 868692-62:
(8*8)+(7*6)+(6*8)+(5*6)+(4*9)+(3*2)+(2*6)+(1*2)=240
240 % 10 = 0
So 868692-62-0 is a valid CAS Registry Number.

868692-62-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-cyano-2-iodo-5-(trifluoromethyl)phenyl]methanesulfonamide

1.2 Other means of identification

Product number -
Other names Methanesulfonamide,N-[4-cyano-2-iodo-5-(trifluoromethyl)phenyl]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:868692-62-0 SDS

868692-62-0Relevant articles and documents

A bioisosteric approach to the discovery of indole carbinol androgen receptor ligands

Lanter, James C.,Fiordeliso, James J.,Allan, George F.,Musto, Amy,Hahn, Do Won,Sui, Zhihua

, p. 5646 - 5649 (2007/10/03)

Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiety in the parent compound. Several analogs in the indole series were found to be 10-fold better than bicalutamide in binding to the recombinant androgen receptor binding domain.

Novel indole derivatives as selective androgen receptor modulators (SARMS)

-

Page/Page column 58-59, (2010/02/14)

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

Novel indole derivatives as selective androgen receptor modulators (SARMS)

-

Page/Page column 58-59, (2008/06/13)

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

NOVEL INDOLE DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS)

-

Page/Page column 57, (2008/06/13)

The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

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