- Reactions of l, 3-diethyl-2-thiobarbituric acid with aldehydes: Formation of arylbis(l, 3-diethyl-2-thiobarbitur-5-yl)methanesf and crystallographic evidence for ground state polarisation in l, 3-diethyl-5-[4-(dimethylamino)benzylidene]-2-thiobarbituric a
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The reactions of 1, 3-diethyl-2-thiobarbituric acid (detba) in ethanol at room temperature with 4-(dimethylamino)benzaldehyde (dmabza) or cinnamaldehyde afford the Knoevenagel products 3 and 4, respectively. Under identical conditions, pyridine-4-carbalde
- Adamson, Jason,Coe, Benjamin J.,Grassam, Helen L.,Jeffery, John C.,Coles, Simon J.,Hursthouse, Michael B.
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- Design and synthesis of thiobarbituric acid analogues as potent urease inhibitors
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A series of thiobarbiturates 4a–4e and bis-thiobarbiturates analogues 5a–5o has been synthesized by condensing 1,3-diethylthiobarbituric acid 3 with a variety of aromatic aldehydes with varied structural features and substitution at active methylene position of thiobarbituric acid. Afterward, chemical structures of newly synthesized analogues of thiobarbituric acid were characterized through FT-IR, NMR spectroscopy and mass spectrometry. Subsequently, the inhibitory potential of thiobarbiturates 4a–4e and bis-thiobarbiturates analogues 5a–5o against urease enzyme was evaluated. The inhibitory potential of all synthesized analogues in terms of IC50 value was observed in the range of 8.42 ± 0.32 to 79.34 ± 0.52 μM by comparing with thiourea (IC50 21.25 ± 0.15 μM) as a standard urease inhibitor. Out of these twenty analogues, most of the analogues exhibited potent inhibitory activity against urease. After interesting findings, structure activity relationship (SAR) has been established for all analogues. Docking studies revealed that synthesized analogues interacted with active site residues of bimetallic nickel center of the urease enzyme through, thiolate, π-π stacking and hydrogen bonding interactions.
- Khan, Matee Ullah,Aslam, Misbah,Shahzad, Sohail Anjum,Khan, Zulfiqar Ali,Khan, Nazeer Ahmad,Ali, Muhammad,Naz, Sadia,Rahman, Jameel,Farooq, Umar
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- Acetylcholinesterase and butyrylcholinesterase inhibitory activities of 5-arylidene-N, N-diethylthiobarbiturates
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5-Arylidene-N,N-diethylthiobarbiturates 1-25 were evaluated for their potential against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes and displayed varying degree of inhibition. Based on the IC50 values, compound 6 (ICsu
- Khan, Momin,Rehman, Munir Ur,Qadir, Naveed,Ashraf, Muhammad,Ismail, Tayaba,Ismail, Muhammad,Kanwal,Salar, Uzma,Khan, Khalid Mohammed,Perveen, Shahnaz
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p. 134 - 140
(2020/02/13)
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- Antiglycation activity of N, N-diethylthiobarbiturates derivatives
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Background: Previous identification of N,N-diethylthiobarbiturates as potential α-glucosidase inhibitory potential prompted us to investigate the antiglycation activity of these synthetic compounds (1-25) in order to identify the lead candidates for their
- Ahad, Ghulam,Kanwal,Khan, Ajmal,Khan, Khalid Mohammed,Khan, Momin,Salar, Uzma,Salman, Syed Muhammad,Shah, Sana
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p. 409 - 515
(2020/04/17)
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- Synthesis, molecular modeling and biological evaluation of 5-arylidene- N,N-diethylthiobarbiturates as potential α-glucosidase Inhibitors
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Background: Barbituric acid derivatives are a versatile group of compounds which are identified as potential pharmacophores for the treatment of anxiety, epilepsy and other psychiatric disorders. They are also used as anesthetics and have sound effects on
- Ashraf, Muhammad,Hameed, Abdul,Hussain, Zahid,Khan, Abbas,Khan, Iltaf,Khan, Khalid M.,Khan, Momin,Khan, Sehrish,Perveen, Shahnaz,Rahman, Jameel,Shams, Sulaiman,Ul Mulk, Amir,Ur Rahman, Anis,Wadood, Abdul,Zaman, Khair
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p. 175 - 185
(2019/07/12)
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- Structurally simple D–A-type organic sensitizers for dye-sensitized solar cells: effect of anchoring moieties on the cell performance
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Abstract: In this work, we report synthesis and device fabrication studies of four metal-free D–A-type dyes (A1–A4) based on structurally simple N,N-dimethyl-4-vinyl aniline carrying four different acceptor/anchoring groups, as sensitizers for sensitizing photoanode (TiO2). In the sensitizers, N,N-dimethylaniline ring acts as an electron donor, while barbituric acid, N,N-dimethyl barbituric acid, thiobarbituric acid and N,N-diethyl thiobarbituric acid function as electron acceptor/anchoring units. They were synthesized in good yield via Knoevenagel protocol in neutral condition without any catalyst. Further, they were subjected to structural, electrochemical and optical characterization in order to evaluate their structure, band gap and absorption/emission behavior. The studies reveal that all the four dyes have thermodynamic feasibility of electron injection as well as electron recombination; their optical band gaps were found to be in the range of 2.35–2.56?eV. High-quality crystals of A2 and A4 were grown by slow evaporation technique using its solution with 1:1 pet ether (60–80?°C)/ethyl acetate solvent mixture at room temperature. Their SC-XRD studies disclose that the crystals are in the triclinic system with space group P-1. Further, DFT studies were performed using Turbomole V7.1 software package to evaluate their optimized geometry and HOMO and LUMO levels. Finally, DSSC device fabricated with the dye A1 showed relatively good efficiency when compared to other dyes mainly due to the effective binding of barbituric acid on the surface of TiO2 through NH or OH functional group. Graphical Abstract: [Figure not available: see fulltext.].
- Naik, Praveen,Su, Rui,Babu, Dickson D.,El-Shafei, Ahmed,Adhikari, Airody Vasudeva
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p. 2457 - 2466
(2017/10/30)
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- Solvent-free Knoevenagel condensations and Michael additions in the solid state and in the melt with quantitative yield
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Numerous Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyanoacetate in stoichiometric mixtures of the solids or of stoichiometri
- Kaupp, Gerd,Naimi-Jamal, M. Reza,Schmeyers, Jens
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p. 3753 - 3760
(2007/10/03)
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- Synthesis and nonlinear optical properties of p-(dimethylamino)benzylidene dyes containing different acceptors
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Several p-(dimethylamino)benzylidene dyes were synthesized and their evaluation of β using Hyper-Rayleigh Scattering (HRS) technique was reported. The results show that these dyes have enhanced second-order hyperpolarizabilities.
- Zheng, Qingdong,Yao, Zuguang,Cheng, Jiqi,Shen, Yaochun,Lu, Zuhong
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p. 1426 - 1427
(2007/10/03)
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