869355-51-1

Basic information

• Product Name: 5-FLUORO-2'-O-METHYL-4-THIOURIDINE
• Synonyms: 5-FLUORO-2'-O-METHYL-4-THIOURIDINE
• CAS NO: 869355-51-1
• Molecular Formula: C₁₀H₁₃FN₂O₅S
• Molecular Weight: 292.28
• Mol File: 869355-51-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-FLUORO-2'-O-METHYL-4-THIOURIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2'-O-METHYL-4-THIOURIDINE(869355-51-1)
• EPA Substance Registry System: 5-FLUORO-2'-O-METHYL-4-THIOURIDINE(869355-51-1)

Safety Data

• Hazardous Substances Data: 869355-51-1(Hazardous Substances Data)

Usage

Uses

Used in Fluorescence Applications:
5-FLUORO-2'-O-METHYL-4-THIOURIDINE is used as a fluorescent probe for the formation of highly efficient fluorescent photoadducts of DNA duplexes. Its incorporation into DNA molecules allows for the study of DNA structure, dynamics, and interactions with other molecules, providing valuable insights into the mechanisms of DNA-related processes.
Used in Biochemical Research:
In the field of biochemical research, 5-FLUORO-2'-O-METHYL-4-THIOURIDINE serves as a useful tool for investigating the mechanisms of nucleic acid synthesis, repair, and degradation. Its unique chemical properties enable researchers to monitor and manipulate these processes, contributing to a better understanding of the molecular basis of various biological phenomena.
Used in Drug Development:
5-FLUORO-2'-O-METHYL-4-THIOURIDINE also holds potential in drug development, particularly in the design of novel therapeutic agents targeting nucleic acid metabolism. Its unique structure and properties can be exploited to develop new drugs with improved efficacy, selectivity, and reduced side effects, addressing unmet medical needs in various disease areas.
Used in Diagnostic Applications:
In diagnostic applications, 5-FLUORO-2'-O-METHYL-4-THIOURIDINE can be employed as a fluorescent marker for the detection and quantification of nucleic acids in various biological samples. Its incorporation into DNA or RNA molecules allows for the sensitive and specific detection of target sequences, facilitating the diagnosis of diseases and the monitoring of treatment responses.
Used in Nanotechnology:
5-FLUORO-2'-O-METHYL-4-THIOURIDINE can also be utilized in the field of nanotechnology, where it can be incorporated into nanostructures for the development of novel materials with unique optical, electronic, and sensing properties. Its ability to form fluorescent photoadducts with DNA can be harnessed to create nanoscale devices for the detection, imaging, and manipulation of biological molecules.

Relevant articles and documents

5-Fluoro-4-thiouridine phosphoramidite: New synthon for introducing photoaffinity label into oligodeoxynucleotides

The synthesis of phosphoramidite of 5-fluoro-4-thio-2′-O- methyluridine is described. An appropriate set of protecting groups was optimized including the 4-thio function introduced via 4-triazolyl as the 4-(2-cyanoethyl)thio derivative, and the t-butyldimethyl silyl for 2′ and 3′ hydroxyl protection, enabling efficient synthesis of the phosphoramidite. These protecting groups prevented unwanted side reactions during oligonucleotide synthesis. The utility of the proposed synthetic route was proven by the preparation of several oligonucleotides via automated synthesis. Photochemical experiments confirmed the utility of the synthon.