869478-16-0

Basic information

• Product Name: tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate
• Synonyms: tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate
• CAS NO: 869478-16-0
• Molecular Formula: C₁₆H₂₁ClN₂O₃
• Molecular Weight: 325
• Mol File: 869478-16-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate(869478-16-0)
• EPA Substance Registry System: tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate(869478-16-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 869478-16-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate is used as a building block for the synthesis of various drugs and biologically active molecules. Its unique chemical structure allows for the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate is also used as a building block in the development of new agrochemicals, contributing to the creation of innovative products for agricultural applications.
Used in Materials Science:
Tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate has potential applications in the field of materials science, where its unique chemical structure can be utilized to develop new materials with specific properties.
Used as a Reagent in Organic Synthesis:
In the field of organic chemistry, tert-Butyl 4-(4-chloro-2-formylphenyl)tetrahydro-1(2H)-pyrazinecarboxylate serves as a reagent in various synthesis processes, enabling the creation of a wide range of organic compounds for research and industrial purposes.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 96515-79-6 5-chloro-2-fluorobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 869478-41-1 4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 
• 869478-26-2 4-{4-chloro-2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Spiroindolinone Derivatives

There are provided compounds of the formula and pharmaceutically acceptable salts and esters and enantiomers thereof wherein W, X, X′, Y, V, V′, A, B and R are as described herein. The compounds have utility as antiproliferative agents, especially, as anticancer agents.

Design, synthesis, in vitro, and in vivo characterization of phenylpiperazines and pyridinylpiperazines as potent and selective antagonists of the melanocortin-4 receptor

Benzylamine and pyridinemethylamine derivatives were synthesized and characterized as potent and selective antagonists of the melanocortin-4 receptor (MC4R). These compounds were also profiled in rodents for their pharmacokinetic properties. Two compounds with diversified profiles in chemical structure, pharmacological activities, and pharmacokinetics, 10 and 12b, showed efficacy in an established murine cachexia model. For example, 12b had a Ki value of 3.4 nM at MC4R, was more than 200-fold selective over MC3R, and had a good pharmacokinetic profile in mice, including high brain penetration. Moreover, 12b was able to stimulate food intake in the tumor-bearing mice and reverse their lean body mass loss. Our results provided further evidence that a potent and selective MC4R antagonist with appropriate pharmacokinetic properties might potentially be useful for the treatment of cancer cachexia.

Practical asymmetric synthesis of α-branched 2- piperazinylbenzylamines by 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines

2-[4-(tert-Butoxycarbonyl)piperazinyl] benzylidene-tert-butanesulfinamides underwent nucleophilic 1,2-addition with different organometallic reagents to give highly diastereomerically enriched adducts. X-ray crystallography of the resulting α-branched N-B