- Aromatic Fluoroalkoxylation via Direct Displacement of a Nitro or Fluoro Group
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Nitro- and fluorobenzenes substituted with a range of electron-withdrawing groups readily undergo fluoroalkoxylation via direct displacement of the nitro or fluoro group.A number of compounds, which cannot be usefully prepared by direct displacement of a chloro group and which are otherwise inaccessible, have been synthesized.Yields and reaction conditions are comparable to those reported by other workers for reactions involving strong nucleophiles.
- Idoux, John P.,Madenwald, Mark L.,Garcia, Brent S.,Chu, Der-Lun,Gupton, John T.
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p. 1876 - 1878
(2007/10/02)
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- Aromatic Fluoroalkoxylation via Direct Aromatic Nucleophilic Substitution
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The reaction of activated aryl and heteroaryl halides with fluorinated alkoxide anions is described.In all cases, substitution of the halogen by a fluoroalkoxy group was observed.The effect of solvent, time, temperature, the activating group, leaving group, and the nucleophile on this reaction is also discussed.
- Idoux, John P.,Gupton, John T.,McCurry, Cynthia K.,Crews, A. Donald,Jurss, Cindy D.,et al.
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p. 3771 - 3773
(2007/10/02)
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