87014-32-2Relevant academic research and scientific papers
Aromatic Fluoroalkoxylation via Direct Displacement of a Nitro or Fluoro Group
Idoux, John P.,Madenwald, Mark L.,Garcia, Brent S.,Chu, Der-Lun,Gupton, John T.
, p. 1876 - 1878 (2007/10/02)
Nitro- and fluorobenzenes substituted with a range of electron-withdrawing groups readily undergo fluoroalkoxylation via direct displacement of the nitro or fluoro group.A number of compounds, which cannot be usefully prepared by direct displacement of a chloro group and which are otherwise inaccessible, have been synthesized.Yields and reaction conditions are comparable to those reported by other workers for reactions involving strong nucleophiles.
Aromatic Fluoroalkoxylation via Direct Aromatic Nucleophilic Substitution
Idoux, John P.,Gupton, John T.,McCurry, Cynthia K.,Crews, A. Donald,Jurss, Cindy D.,et al.
, p. 3771 - 3773 (2007/10/02)
The reaction of activated aryl and heteroaryl halides with fluorinated alkoxide anions is described.In all cases, substitution of the halogen by a fluoroalkoxy group was observed.The effect of solvent, time, temperature, the activating group, leaving group, and the nucleophile on this reaction is also discussed.
