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870221-22-0

4-(2-Chloro-3-pyridinyl)-N-methyl-2-pyrimidinamine, also known as chlorpyrifos-methyl, is an organophosphate chemical compound that functions as a widely used pesticide in agricultural settings. It is effective in controlling a broad spectrum of insect pests, operating through the disruption of the insects' nervous systems, which results in paralysis and death. Despite its efficacy, concerns regarding its potential health risks for humans and non-target organisms have prompted regulatory measures to mitigate its impact on health and the environment.

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  • 870221-22-0 Structure

  • Basic information

    1. Product Name: 4-(2-Chloro-3-pyridinyl)-N-Methyl-2-pyriMidinaMine
    2. Synonyms: 2-pyrimidinamine, 4-(2-chloro-3-pyridinyl)-N-methyl-; 4-(2-Chloropyridin-3-yl)-N-methylpyrimidin-2-amine
    3. CAS NO:870221-22-0
    4. Molecular Formula: C10H9ClN4
    5. Molecular Weight: 220.65826
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 870221-22-0.mol

  • Chemical Properties

    1. Melting Point: 187～189℃
    2. Boiling Point: 401.1°C at 760 mmHg
    3. Flash Point: 196.4°C
    4. Appearance: /
    5. Density: 1.33g/cm3
    6. Vapor Pressure: 1.21E-06mmHg at 25°C
    7. Refractive Index: 1.638
    8. Storage Temp.: 2-8°C
    9. Solubility: N/A
    10. CAS DataBase Reference: 4-(2-Chloro-3-pyridinyl)-N-Methyl-2-pyriMidinaMine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(2-Chloro-3-pyridinyl)-N-Methyl-2-pyriMidinaMine(870221-22-0)
    12. EPA Substance Registry System: 4-(2-Chloro-3-pyridinyl)-N-Methyl-2-pyriMidinaMine(870221-22-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 870221-22-0(Hazardous Substances Data)

870221-22-0 Usage

Uses

Used in Agricultural Industry:
4-(2-Chloro-3-pyridinyl)-N-methyl-2-pyrimidinamine is used as an insecticide for controlling a variety of insect pests that can damage crops and reduce agricultural productivity. Its application aims to protect crops from these pests, ensuring a stable food supply and contributing to economic sustainability in the agricultural sector.
However, due to the potential health risks associated with chlorpyrifos-methyl, its use is subject to strict regulations in various countries. These regulations aim to balance the need for effective pest control with the protection of human health and the environment. Alternative pest control methods and safer chemical compounds are being explored to reduce reliance on organophosphates like chlorpyrifos-methyl.

Check Digit Verification of cas no

The CAS Registry Mumber 870221-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,2,2 and 1 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 870221-22:
(8*8)+(7*7)+(6*0)+(5*2)+(4*2)+(3*1)+(2*2)+(1*2)=140
140 % 10 = 0
So 870221-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H9ClN4/c1-12-10-14-6-4-8(15-10)7-3-2-5-13-9(7)11/h2-6H,1H3,(H,12,14,15)

870221-22-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2-chloropyridin-3-yl)-N-methylpyrimidin-2-amine

1.2 Other means of identification

Product number -
Other names chloropyridinylmethylpyrimidinamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:870221-22-0 SDS

870221-22-0Relevant articles and documents

Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor

Hodous, Brian L.,Geuns-Meyer, Stephanie D.,Hughes, Paul E.,Albrecht, Brian K.,Bellon, Steve,Bready, James,Caenepeel, Sean,Cee, Victor J.,Chaffee, Stuart C.,Coxon, Angela,Emery, Maurice,Fretland, Jenne,Gallant, Paul,Gu, Yan,Hoffman, Doug,Johnson, Rebecca E.,Kendall, Richard,Kim, Joseph L.,Long, Alexander M.,Morrison, Michael,Olivieri, Philip R.,Patel, Vinod F.,Polverino, Anthony,Rose, Paul,Tempest, Paul,Wang, Ling,Whittington, Douglas A.,Zhao, Huilin

, p. 611 - 626 (2007/10/03)

Inhibition of angiogenesis is a promising and clinically validated approach for limiting tumor growth and survival. The receptor tyrosine kinase Tie-2 is expressed almost exclusively in the vascular endothelium and is required for developmental angiogenes

PROTEIN KINASE MODULATORS AND METHOD OF USE

-

Page/Page column 135, (2010/02/14)

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

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