870703-62-1Relevant articles and documents
Synthesis of aryl ketones by palladium(II)-catalyzed decarboxylative addition of benzoic acids to nitriles
Lindh, Jonas,Sjoeberg, Per J. R.,Larhed, Mats
supporting information; experimental part, p. 7733 - 7737 (2011/01/05)
An efficient, sustainable method for the preparation of aryl ketones from ortho-substituted benzoic acids proceeds through their decarboxylation to generate an aryl-palladium species, followed by addition to a nitrile and hydrolysis of the intermediate ketimine.
Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides
Xu, Dan,Liu, Zhihua,Tang, Weijun,Xu, Lijin,Hyder, Zeynab,Xiao, Jianliang
body text, p. 6104 - 6107 (2009/04/04)
A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd(OAc)2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety of heteroaryl halides reacted very quickly with electron-rich olefins to afford exclusively the branched products in good to excellent yields without employing triflates, halide scavengers, or ionic liquids.
