870849-40-4

Basic information

• Product Name: 1-(2,6-Difluorophenyl)ethan-1-amine
• Synonyms: 1-(2,6-Difluorophenyl)ethan-1-amine;1-(2,6-difluorophenyl)ethan-1-aMine (raceMic) HCL;2,6-Difluoro-alpha-methylbenzenemethanamine;1-(2,6-Difluorophenyl)ethylamine
• CAS NO: 870849-40-4
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 157.1605664
• Mol File: 870849-40-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-(2,6-Difluorophenyl)ethan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,6-Difluorophenyl)ethan-1-amine(870849-40-4)
• EPA Substance Registry System: 1-(2,6-Difluorophenyl)ethan-1-amine(870849-40-4)

Safety Data

• Hazardous Substances Data: 870849-40-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
1-(2,6-Difluorophenyl)ethan-1-amine is utilized as a precursor compound for the synthesis of other pharmaceuticals, leveraging its chemical structure to create new therapeutic agents. Its role in this application is to provide a foundation for the development of medications with potential psychoactive properties.
Used in Research and Development:
In the field of neuroscience, 1-(2,6-Difluorophenyl)ethan-1-amine is employed as a research tool to study the mechanisms of neurotransmission and receptor interactions in the brain. Its use in this capacity aids scientists in understanding the complex dynamics of brain chemistry and may contribute to the discovery of novel treatments for neurological disorders.
Used in Medicinal Chemistry:
1-(2,6-Difluorophenyl)ethan-1-amine is applied as a key intermediate in the design and synthesis of new compounds with therapeutic effects. Its unique structure allows for the exploration of various chemical modifications, potentially leading to the creation of innovative medications with improved efficacy and safety profiles.
Overall, 1-(2,6-Difluorophenyl)ethan-1-amine's applications are multifaceted, reflecting its importance in both the advancement of pharmaceuticals and the pursuit of scientific knowledge in the realms of neuroscience and medicinal chemistry.

Upstream product

• 13670-99-0 2,6-difluoroacetophenone 
• 87327-65-9 2,6-Difluoro-alpha-methylbenzyl alcohol 

Relevant articles and documents

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.

Transaminases applied to the synthesis of high added-value enantiopure amines

Critical parameters affecting the stereoselective amination of (hetero)aromatic ketones using transaminases have been studied, such as temperature, pH, substrate concentration, cosolvent, and source and percentage of amino donor, to further optimize the production of enantiopure amines using both (S)- and (R)-selective biocatalysts from commercial suppliers. Interesting enantiopure amino building blocks have been obtained, overcoming some limitations of traditional chemical synthetic methods. Representative processes were scaled up, affording halogenated and heteroaromatic amines in enantiomerically pure form and good isolated yields.