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(2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA is a chemical compound that functions as a selective inhibitor of excitatory amino acid transporters (EAATs). It is utilized in research to understand the role of EAATs in synaptic transmission and their function. (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA holds promise for potential applications in treating neurological disorders due to its influence on the regulation of glutamate levels in the brain, a critical neurotransmitter in various neurological processes.
Used in Pharmaceutical Industry:
(2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA is used as a research compound for studying the function of excitatory amino acid transporters (EAATs) and their role in synaptic transmission. This understanding is crucial for developing treatments for neurological disorders.
Used in Neurological Research:
(2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA is used as a therapeutic agent in the investigation of potential treatments for conditions such as epilepsy and ischemia. Its ability to regulate glutamate levels in the brain makes it a promising candidate for managing these neurological conditions.

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  • 871123-98-7 Structure
  • Basic information

    1. Product Name: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA
    2. Synonyms: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA;L-β-threo-benzyl-aspartate ammonium salt;(2S,3S)-2-Amino-3-benzylsuccinic acid;L-β-threo-benzyl-aspartate;(3S)-3-(Phenylmethyl)-L-aspartic acid
    3. CAS NO:871123-98-7
    4. Molecular Formula: C11H13NO4
    5. Molecular Weight: 223.23
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 871123-98-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA(871123-98-7)
    11. EPA Substance Registry System: (2S,3S)-2-Amino-3-benzylsuccinic ammonium salt, DL-TBOA(871123-98-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 871123-98-7(Hazardous Substances Data)

871123-98-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 871123-98-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,1,2 and 3 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 871123-98:
(8*8)+(7*7)+(6*1)+(5*1)+(4*2)+(3*3)+(2*9)+(1*8)=167
167 % 10 = 7
So 871123-98-7 is a valid CAS Registry Number.

871123-98-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name L-Aspartic acid, 3-(phenylmethyl)-, (3S)-

1.2 Other means of identification

Product number -
Other names L-Beta-threo-benzyl-aspartate ammonium salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:871123-98-7 SDS

871123-98-7Downstream Products

871123-98-7Relevant articles and documents

Structure-guided engineering of: Pseudomonas dacunhae l-aspartate β-decarboxylase for l-homophenylalanine synthesis

Zhang, Min,Hu, Pengfei,Zheng, Yu-Cong,Zeng, Bu-Bing,Chen, Qi,Zhang, Zhi-Jun,Xu, Jian-He

, p. 13876 - 13879 (2020/11/18)

Structure-guided engineering of Pseudomonas dacunhael-aspartate β-decarboxylase (AspBDC) resulted in a double mutant (R37A/T382G) with remarkable 15400-fold improvement in specific activity reaching 216 mU mg-1, towards the target substrate 3(R)-benzyl-l-aspartate. A novel strategy for enzymatic synthesis of l-homophenylalanine was developed by using the variant as a biocatalyst affording 75% product yield within 12 h. Our results underscore the potential of engineered AspBDC for the biocatalytic synthesis of pharmaceutically relevant and value added unnatural l-amino acids.

Synthesis and preliminary pharmacological evaluation of novel derivatives of l-β-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3

Mavencamp, Terri L.,Rhoderick, Joseph F.,Bridges, Richard J.,Esslinger, C. Sean

, p. 7740 - 7748 (2008/12/23)

A series of β-benzylaspartate derivatives were prepared from N-trityl-l-aspartate dimethyl ester and evaluated as inhibitors of neuronal glutamate transporter EAAT3. The result of the structure-activity studies suggests that the position occupied by the aromatic ring of β-benzylaspartate within the binding site of EAAT3 may be different from that occupied by comparable groups in previously identified inhibitors, such as l-threo-benzyloxy aspartate (TBOA). Further, halogen substitutions at the 3-postition of the aromatic ring of β-benzylaspartate can increase the potency with which the analogues inhibit EAAT3.

3-alkylaryl aspartate compounds and their use for selective enhancement of synaptic transmission

-

Page/Page column 5-6, (2010/11/27)

The present invention provides an L-aspartate derivative compound represented by the following structure wherein Ar represents an aromatic group; L represents a linking moiety; R represents hydrogen, alkyl, aryl, or heteroaryl; and indicates that the stereochemistry at the 3-position can be R or S. The compounds of the invention are useful for selectively inhibiting EAAT3 and for enhancing synaptic transmission. Additionally, the inventive compounds can be used to treat a patient suffering from Alzheimers disease or a neuropathy or a neurodegenerative disease in which L-glutamate transporter activity is involved in the onset of the disease.

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