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BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 871656-49-4 Structure
  • Basic information

    1. Product Name: BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER
    2. Synonyms: 3-BENZYLOXY-5-(4-METHANESULFONYL-PHENOXY)-BENZOIC ACID METHYL ESTER;BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER
    3. CAS NO:871656-49-4
    4. Molecular Formula: C22H20O6S
    5. Molecular Weight: 412.46
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 871656-49-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER(CAS DataBase Reference)
    10. NIST Chemistry Reference: BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER(871656-49-4)
    11. EPA Substance Registry System: BENZOIC ACID, 3-[4-(METHYLSULFONYL)PHENOXY]-5-(PHENYLMETHOXY)-, METHYL ESTER(871656-49-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 871656-49-4(Hazardous Substances Data)

871656-49-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 871656-49-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,6,5 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 871656-49:
(8*8)+(7*7)+(6*1)+(5*6)+(4*5)+(3*6)+(2*4)+(1*9)=204
204 % 10 = 4
So 871656-49-4 is a valid CAS Registry Number.

871656-49-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 3-(4-methylsulfonylphenoxy)-5-phenylmethoxybenzoate

1.2 Other means of identification

Product number -
Other names 3-(4-methylsulfonylphenoxy)-5-phenylmethoxybenzoic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:871656-49-4 SDS

871656-49-4Relevant articles and documents

Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation

Wang, Zhengyu,Shi, Xiaofan,Zhang, Huan,Yu, Liang,Cheng, Yanhua,Zhang, Hefeng,Zhang, Huibin,Zhou, Jinpei,Chen, Jing,Shen, Xu,Duan, Wenhu

, p. 128 - 152 (2017/08/10)

Glucokinase (GK) activators are being developed for the treatment of type 2 diabetes mellitus (T2DM). However, existing GK activators have risks of hypoglycemia caused by over-activation of GK in islet cells and dyslipidemia caused by over-activation of intrahepatic GK. In the effort to mitigate risks of hypoglycemia and dyslipidemia while maintaining the promising efficacy of GK activator, we investigated a series of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific partial GK activators, which led to the identification of compound 72 that showed a good balance between in vitro potency and enzyme kinetic parameters, and protected β-cells from streptozotocin-induced apoptosis. Chronic treatment of compound 72 demonstrated its potent activity in regulation of glucose homeostasis and low risk of dyslipidemia with diabetic db/db mice in oral glucose tolerance test (OGTT). Moreover, acute treatment of compound 72 did not induce hypoglycemia in C57BL/6J mice even at 200 mg/kg via oral administration.

HETROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES

-

, (2008/06/13)

Compounds of Formula (I) wherein: R1 is hydroxymethyl; R2 is selected from -C(O)NR4R5, SO2NR4R5, S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring; HET-2 is a 4-, 5- or 6-membered, C- or N-linked optionally substituted heterocyclyl ring; R3 is selected from halo, fluoromethyl, difluoromethyl, trifluoromethyl, methyl, methoxy and cyano; R4 is selected from for example hydrogen, optionally substituted (1-4C)alkyl and HET-2; R5 is hydrogen or (1-4C)alkyl; or R4 and R5 together with the nitrogen atom to which they are attached may form a heterocyclyl ring system as defined by HET-3; HET-3 is for example an optionally substituted N-linked, 4, 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring; p is (independently at each occurrence) 0, 1 or 2; m is 0 or 1; n is 0, 1 or 2; provided that when m is 0, then n is 1 or 2; or a salt, pro drug or solvate thereof, are described. Their use as GLK activators, pharmaceutical compositions containing them, and processes for their preparation are also described.

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