cas 872254-32-5, 1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

Articles about 872254-32-5Total 3 be found

ISATIN ANALOGUES AND USES THEREFOR
Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vi
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(2009/04/24)

Isatin sulfonamide analogs containing a Michael addition acceptor: A new class of caspase 3/7 inhibitors
A series of isatin sulfonamide analogs having a Michael acceptor were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated. These compounds have nanomolar potency for inhibiting the executioner caspases, caspase-3 and c
Chu, Wenhua,Rothfuss, Justin,D'Avignon, André,Zeng, Chenbo,Zhou, Dong,Hotchkiss, Richard S.,Mach, Robert H.
p. 3751 - 3755
(2008/02/10)

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: Synthesis, in vitro activity, and molecular modeling studies
A number of isatin sulfonamide analogues were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated in vitro. Several compounds displaying a nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspas
Chu, Wenhua,Zhang, Jun,Zeng, Chenbo,Rothfuss, Justin,Tu, Zhude,Chu, Yunxiang,Reichert, David E.,Welch, Michael J.,Mach, Robert H.
p. 7637 - 7647
(2007/10/03)