Novel isatin analogues, including isatin analogues comprising Michael Acceptors (IMAs) are disclosed. Further disclosed are methods of synthesis of the isatin analogues, and uses of the analogues, including inhibition of caspase-3 and caspase-7, and in vi
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Page/Page column 13
(2009/04/24)
N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: Synthesis, in vitro activity, and molecular modeling studies
A number of isatin sulfonamide analogues were prepared and their potencies for inhibiting caspase-1, -3, -6, -7, and -8 were evaluated in vitro. Several compounds displaying a nanomolar potency for inhibiting the executioner caspases, caspase-3 and caspas
Chu, Wenhua,Zhang, Jun,Zeng, Chenbo,Rothfuss, Justin,Tu, Zhude,Chu, Yunxiang,Reichert, David E.,Welch, Michael J.,Mach, Robert H.
p. 7637 - 7647
(2007/10/03)
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