86661-32-7

Basic information

• Product Name: (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE
• Synonyms: (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE;1-Pyrrolidinecarboxylic acid, 2-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-, 1,1-diMethylethyl ester, (2S)-;((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)Methyl 4-Methylbenzenesulfonate
• CAS NO: 86661-32-7
• Molecular Formula: C₁₇H₂₅NO₅S
• Molecular Weight: 355.453
• Mol File: 86661-32-7.mol
• Article Data: 83

Chemical Properties

• Boiling Point: 474.547 °C at 760 mmHg
• Flash Point: 240.798 °C
• Appearance: /
• Density: 1.197 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE(86661-32-7)
• EPA Substance Registry System: (S)-TERT-BUTYL 2-(TOSYLOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE(86661-32-7)

Safety Data

• Hazardous Substances Data: 86661-32-7(Hazardous Substances Data)

Usage

General Description

(S)-tert-Butyl 2-(tosyloxymethyl)pyrrolidine-1-carboxylate is a chemical compound that has a pyrrolidine ring structure with a tert-butyl group and a tosyloxymethyl group attached to it. It is commonly used as a chemical intermediate in the synthesis of pharmaceuticals and other organic compounds. (S)-tert-Butyl 2-(tosyloxymethyl)pyrrolidine-1-carboxylate is a derivative of pyrrolidine-1-carboxylic acid and is often used as a chiral building block in organic synthesis. Due to its versatility and stability, it is widely used in the pharmaceutical and chemical industries for the production of various drugs and other compounds. The tosyloxymethyl group in this compound serves as a protecting group, which is often used to selectively modify the reactivity of certain functional groups in organic synthesis.

InChI:InChI=1/C17H25NO5S/c1-13-7-9-15(10-8-13)24(20,21)22-12-14-6-5-11-18(14)16(19)23-17(2,3)4/h7-10,14H,5-6,11-12H2,1-4H3/t14-/m0/s1

Upstream product

• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 98-59-9 p-toluenesulfonyl chloride 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 616-47-7 1-methyl-1H-imidazole 
• 135097-23-3 (2S)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 84890-94-8 (S)-2-Isobutoxycarbonyloxycarbonyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 147-85-3 L-proline 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 224620-23-9 (S)-(-)-N-tert-butoxycarbonyl-2-<(bis(4-N,N-dimethylaminophenyl)phosphino)methyl>pyrrolidine 
• 145818-31-1 (S)-(+)-N-(N',N'-dimethylcarbamoyl)-2-<(diphenylphosphino)methyl>pyrrolidine 
• 929917-26-0 (S)-2-(4-benzylphenoxymethyl)-1-BOC-pyrrolidine 
• 929917-42-0 (S)-2-[4-(4-chlorophenoxy)phenoxymethyl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 929917-54-4 (S)-2-(4-p-Tolyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 929917-99-7 (S)-2-(4-Benzyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 142253-50-7 (S)-2-cyanomethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 460748-80-5 (2R)-2-ethylpyrrolidine hydrochloride 
• 876617-06-0 tert-butyl (2R)-2-ethylpyrrolidine-1-carboxylate 
• 174213-76-4 (S)-2-(phenoxymethyl)-pyrrolidine 
• 118656-45-4 tert-butyl (2S)-2-[(phenylsulfanyl)methyl]pyrrolidine-1-carboxylate 
• 73236-85-8 (S)-2-<(acetylthio)methyl>-1-<(tert-butyloxy)carbonyl>pyrrolidine 
• 77489-32-8 Boc-ProψGly-OH 
• 53310-83-1 (S)-tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-3-one 

Relevant articles and documents

PYRAZOLE AND IMIDAZOLE DERIVATIVES, COMPOSITIONS AND METHODS AS OREXIN ANTAGONISTS

The present invention is directed to substituted Pyrazole and Imidazole derivatives of compounds that are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which

Chiral phosphine nitrogen phosphine ligand and chiral metal organic coordination complex and application

The invention discloses a chiral phosphine nitrogen phosphine ligand and chiral metal organic coordination complex and application. The chiral tridentate phosphine nitrogen phosphine ligand is shown as a formula (I), and the chiral metal organic coordination complex is shown as a formula (II), wherein the chiral metal organic coordination complex shown as the formula (II) is used as a homogeneouscatalyst to be applied to preparation of phenylalanine derivatives with high optical activity. The novel chiral nitrogen-phosphine ligand synthesized by taking cheap amino acid as a chiral source is applied to asymmetric hydrogenation reaction, and a chiral product with relatively high yield can be obtained with relatively low catalytic dosage, relatively short reaction time and relatively mild reaction conditions.

Synthesis and Stereochemical Assignment of Conioidine A: DNA- And HSA-Binding Studies of the Four Diastereomers

Conioidine A (1), isolated in 1993 with unknown relative and absolute configuration, was suggested to be a DNA-binding compound by an indirect technique. Four stereoisomers of conioidine A have been synthesized from d- and l-proline, and the natural product has been identified as possessing (4R,6R) absolute configuration. Binding of the conioidine diastereomers to calf thymus DNA (CT DNA) and human serum albumin (HSA) has been investigated by fluorescence spectroscopy and isothermal titration calorimetry (ITC). All stereoisomers display at least an order of magnitude weaker binding to DNA than the control compound netropsin; however, a strong association with HSA was observed for the (4R,6S) stereoisomer.