873-41-6

Basic information

• Product Name: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE
• Synonyms: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE;Trichloro-1,2,4-triazine
• CAS NO: 873-41-6
• Molecular Formula: C₃Cl₃N₃
• Molecular Weight: 184.4112
• Product Categories: Heterocycle-other series
• Mol File: 873-41-6.mol

Chemical Properties

• Melting Point: 57-58℃
• Boiling Point: 337.3ºC at 760 mmHg
• Flash Point: 188.209ºC
• Appearance: /
• Density: 1.757g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.55±0.63(Predicted)
• CAS DataBase Reference: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE(873-41-6)
• EPA Substance Registry System: 3,5,6-TRICHLORO-[1,2,4]TRIAZINE(873-41-6)

Safety Data

• Hazardous Substances Data: 873-41-6(Hazardous Substances Data)

Usage

Uses

3,5,6-Trichloro-[1,2,4]triazine (cas# 873-41-6) is a compound useful in organic synthesis.

InChI:InChI=1/C3Cl3N3/c4-1-2(5)8-9-3(6)7-1

Upstream product

• 4956-05-2 6-bromo-1,2,4-triazine-3,5(2H,4H)-dione 

Downstream Products

• 41789-37-1 2,6-dichloro-5-pyridylmethyl chloride 
• 132434-84-5 5-phenoxy-3,6-dichloro-1,2,4-triazine 
• 132434-85-6 5-phenylthio-3,6-dichloro-1,2,4-triazine 
• 132434-83-4 5-phenyl-3,6-dichloro-1,2,4-triazine 
• 83403-50-3 3,6-dichloro-N-phenyl-1,2,4-triazin-5-amine 
• 114722-54-2 1,3-dichloro-6,7,8,9-tetrahydro-5H-cycloheptapyridine 
• 946403-39-0 3,5-N,N-dibenzylamino-6-chloro-1,2,4-triazine 
• 946403-38-9 5-N-benzylamino-3,6-dichloro-1,2,4-triazine 
• 823-62-1 3,6-dichloro-1,2,4-triazine-5-amine 

Relevant articles and documents

Discovery of 1,2,4-triazine-based derivatives as novel neddylation inhibitors and anticancer activity studies against gastric cancer MGC-803 cells

Neddylation modification is often over-expressed in a variety of human tumor cells. Therefore, targeting neddylation pathway may represent a potential approach to the treatment of human tumors. Herein, we describe the discovery of a hit scaffold from our

Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity

A series of 1,3,5-triazinic inhibitors of focal adhesion kinase (FAK) has recently been shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. In this report, we designed and synthesized a series of new compounds containing a 1,2,4-triazine core as novel scaffold for FAK inhibitors. These compounds displayed 10?7?M IC50 values, and the best one showed IC50 value of 0.23?μM against FAK enzymatic activity. Among them, several inhibitors potently inhibited the proliferation of glioblastoma (U-87MG) and colon (HCT-116) cancer cell lines. Docking of compound 10 into the active site of the FAK kinase was performed to explore its potential binding mode.

HIV INHIBITING 1,2,4-TRIAZIN-6-ONE DERIVATIVES

The present invention relates to HIV replication inhibitors of formula (I) a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein ring A and ring B represent phenyl, pyridyl, pyridaz

HIV INHIBITING 1,2,4-TRIAZINES

The present invention relates to HIV replication inhibitors of formula (I) as defined in the specification their use as a medicine, their processes for preparation and pharmaceutical compositions comprising them.

Heterocyclic Polyfluoro-compounds. Part 39. Preparation and some Nucleophilic Substitution Reactions of Trifluoro-1,2,4-triazine

Fluorination of trichloro-1,2,4-triazine over potassium fluoride at 450 deg C in a flow system yields trifluoro-(91percent) and 6-chloro-3,5-difluoro-1,2,4-triazine (5percent).The trifluorotriazine yields a dimer with time, which reverts to the monomer wi